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- Suppressor of cytokine signaling 2 negatively regulates NK cell differentiation by inhibiting JAK2 activity
- Won Sam Kim; Mi Jeong Kim; Dong Oh Kim; Jae-Eun Byun; H Huy; Hae Young Song; Young-Jun Park; Tae-Don Kim; Suk Ran Yoon; E J Choi; Haiyoung Jung; In Pyo Choi
- Bibliographic Citation
- Scientific Reports, vol. 7, pp. 46153-46153
- Publication Year
- Suppressor of cytokine signaling (SOCS) proteins are negative regulators of cytokine responses. Although recent reports have shown regulatory roles for SOCS proteins in innate and adaptive immunity, their roles in natural killer (NK) cell development are largely unknown. Here, we show that SOCS2 is involved in NK cell development. SOCS2 a '/a ' mice showed a high frequency of NK cells in the bone marrow and spleen. Knockdown of SOCS2 was associated with enhanced differentiation of NK cells in vitro, and the transplantation of hematopoietic stem cells (HSCs) into congenic mice resulted in enhanced differentiation in SOCS2 a '/a ' HSCs. We found that SOCS2 could inhibit Janus kinase 2 (JAK2) activity and JAK2-STAT5 signaling pathways via direct interaction with JAK2. Furthermore, SOCS2 a '/a ' mice showed a reduction in lung metastases and an increase in survival following melanoma challenge. Overall, our findings suggest that SOCS2 negatively regulates the development of NK cells by inhibiting JAK2 activity via direct interaction.
- Springer-Nature Pub Group
- Appears in Collections:
- Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
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