Association between perfluorooctanoic acid exposure and degranulation of mast cells in allergic inflammation

Cited 12 time in scopus
Metadata Downloads
Title
Association between perfluorooctanoic acid exposure and degranulation of mast cells in allergic inflammation
Author(s)
J K Lee; Soyoung Lee; M C Baek; B H Lee; H S Lee; T K Kwon; P H Park; T Y Shin; D Khang; S H Kim
Bibliographic Citation
Journal of Applied Toxicology, vol. 37, no. 5, pp. 554-562
Publication Year
2017
Abstract
Perfluorooctanoic acid (PFOA) has wide applications, including as a raw material for converted paper and packaging products. With the widespread use of PFOA, concerns regarding its potential environmental and health impacts have increased. In spite of the known hepatotoxicity and genotoxicity of PFOA, correlation with PFOA and allergic inflammation is not well known. In this study, the effect of PFOA on the degranulation of mast cells and mast cell-mediated allergic inflammation in the presence of FcεRI cross-linking was evaluated. In immunoglobulin (Ig) E-stimulated mast cells, PFOA increased the release of histamine and β-hexosaminidase by the up-regulation of intracellular calcium levels. PFOA enhanced gene expression of several pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-8 by the activation of nuclear factor (NF)-κB in IgE-stimulated mast cells. Also, PFOA exacerbated allergic symptoms via hypothermia, and an increase of serum histamine, TNF-α, IgE and IgG1 in the ovalbumin-induced systemic anaphylaxis. The present data indicate that PFOA aggravated Fc?RI-mediated mast cell degranulation and allergic symptoms.
Keyword
allergic inflammationhistaminemast cellsperfluorooctanoic acid (PFOA)pro-inflammatory cytokine
ISSN
0260-437X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/jat.3389
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.