Crosstalk between T and B cells in the germinal center after transplantation

Cited 46 time in scopus
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Title
Crosstalk between T and B cells in the germinal center after transplantation
Author(s)
J Kwun; M Manook; E Page; C Burghuber; Jung Joo Hong; S J Knechtle
Bibliographic Citation
Transplantation, vol. 101, no. 4, pp. 704-712
Publication Year
2017
Abstract
Crosstalk between B and T cells in transplantation is increasingly recognized as being important in the alloimmune response. T cell activation of B cells occurs by a 3-stage pathway, culminating with costimulation signals. We review the distinct T cell subtypes required for B-cell activation and discuss the formation of the germinal center (GC) after transplantation, with particular reference to the repopulation of the GC after depletional induction, and the subsequent effect of immunosuppressive manipulation of T cell-B cell interactions. In addition, ectopic GCs are seen in transplantation, but their role is not fully understood. Therapeutic options to target T cell-B cell interactions are of considerable interest, both as immunosuppressive tools, and to aid in the further understanding of these important alloimmune mechanisms
ISSN
0041-1337
Publisher
Kluwer
DOI
http://dx.doi.org/10.1097/TP.0000000000001588
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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