Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans

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dc.contributor.authorJi Young Park-
dc.contributor.authorSu Hwan Lim-
dc.contributor.authorBo Ram Kim-
dc.contributor.authorHyung Jae Jeong-
dc.contributor.authorHyung Jun Kwon-
dc.contributor.authorG Y Song-
dc.contributor.authorYoung Bae Ryu-
dc.contributor.authorWoo Song Lee-
dc.date.accessioned2017-08-29-
dc.date.available2017-08-29-
dc.date.issued2017-
dc.identifier.issn0960894X-
dc.identifier.uri10.1016/j.bmcl.2017.05.055ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/17169-
dc.description.abstractSialidases are key virulence factors that remove sialic acid from host cell surface glycans, thus unmasking receptors to facilitate bacterial adherence and colonization. In this study, we report the isolation and characterization of novel inhibitors of the Streptococcus pneumoniae sialidases NanA, NanB, and NanC from Myristica fragrans seeds. Of the isolated compounds (1-12), malabaricone C showed the most pneumococcal sialidases inhibition (IC50 of 0.3μM for NanA, 3.6μM for NanB, and 2.9μM for NanC). These results suggested that malabaricone C and neolignans could be potential agents for combating S. pneumoniae infection agents-
dc.publisherElsevier-
dc.titleSialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans-
dc.title.alternativeSialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number14-
dc.citation.endPage3064-
dc.citation.startPage3060-
dc.citation.volume27-
dc.contributor.affiliatedAuthorJi Young Park-
dc.contributor.affiliatedAuthorSu Hwan Lim-
dc.contributor.affiliatedAuthorBo Ram Kim-
dc.contributor.affiliatedAuthorHyung Jae Jeong-
dc.contributor.affiliatedAuthorHyung Jun Kwon-
dc.contributor.affiliatedAuthorYoung Bae Ryu-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.alternativeName박지영-
dc.contributor.alternativeName임수환-
dc.contributor.alternativeName김보람-
dc.contributor.alternativeName정형재-
dc.contributor.alternativeName권형준-
dc.contributor.alternativeName송규용-
dc.contributor.alternativeName류영배-
dc.contributor.alternativeName이우송-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 27, no. 14, pp. 3060-3064-
dc.identifier.doi10.1016/j.bmcl.2017.05.055-
dc.subject.keywordMalabaricone C-
dc.subject.keywordMyristica fragrans-
dc.subject.keywordNanA-
dc.subject.keywordNanB-
dc.subject.keywordSialidase-
dc.subject.localMalabaricone C-
dc.subject.localMyristica fragrans-
dc.subject.localNanA-
dc.subject.localNanB-
dc.subject.localSialidase-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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