Schwann cell precursors from human pluripotent stem cells as a potential therapeutic target for myelin repair

Cited 31 time in scopus
Metadata Downloads
Title
Schwann cell precursors from human pluripotent stem cells as a potential therapeutic target for myelin repair
Author(s)
Han-Seop KimJungwoon LeeDa Yong Lee; Young-Dae Kim; Jae Yun Kim; Hyung Jin Lim; Sungmin Lim; Yee Sook Cho
Bibliographic Citation
Stem Cell Reports, vol. 8, no. 6, pp. 1714-1726
Publication Year
2017
Abstract
Schwann cells play a crucial role in successful nerve repair and regeneration by supporting both axonal growth and myelination. However, the sources of human Schwann cells are limited both for studies of Schwann cell development and biology and for the development of treatments for Schwann cell-associated diseases. Here, we provide a rapid and scalable method to produce self-renewing Schwann cell precursors (SCPs) from human pluripotent stem cells (hPSCs), using combined sequential treatment with inhibitors of the TGF-β and GSK-3 signaling pathways, and with neuregulin-1 for 18 days under chemically defined conditions. Within 1 week, hPSC-derived SCPs could be differentiated into immature Schwann cells that were functionally confirmed by their secretion of neurotrophic factors and their myelination capacity in vitro and in vivo. We propose that hPSC-derived SCPs are a promising, unlimited source of functional Schwann cells for treating demyelination disorders and injuries to the peripheral nervous system
Keyword
axon regenerationhPSCsmyelinationSchwann cellSchwann cell precursor
ISSN
2213-6711
Publisher
Elsevier-Cell Press
DOI
http://dx.doi.org/10.1016/j.stemcr.2017.04.011
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.