Effect of dietary bioactive compounds and biopolymer encapsulated lipids on metabolism of lipids in high fat diet-fed mice

Abstract

We determined the effects of dietary bioactive components and biopolymer encapsulation on lipids’ metabolism in obese mice. Six random groups of 60 obese mice were fed the following diets for 95 days: Basal diet; cellulose encapsulated lipids; pectin and chitosan encapsulated lipids (EPC); Camellia sinensis and Coix lacryma enhanced diet; C. sinensis and C. lacryma diet plus pectin and chitosan encapsulated lipids; hydroxycitric acid, caffeine, and vitamin C enhanced diet plus pectin and chitosan encapsulated lipids (HCVEPC). The HCVEPC group usually presented lower body and total adipose tissue weight compared to other diet groups. Intestine length was not significantly different among all dietary groups. Serum leptin, triglycerides, and cholesterol were significantly lower in EPC and HCVEPC compared to other groups. However, serum glucose was not significantly different among groups. Our results indicate that bioactive compounds and biopolymers’ encapsulation act synergistically in the reduction of body and adipose tissue weight. Practical applications: Based on the results described above, it is suggested that bioactive components and biopolymer encapsulation with some natural products has synergistically in the reduction of body and adipose tissue weight on in vivo models. In addition, through this results suggest that can be used information and utilization of lipids metabolism, this research is to highlight the potential of selected natural products as a source of functional Substances. Therefore, lipids encapsulated with dietary biopolymers and bioactive compounds should be considered as a prospective functional food and pharmaceuticals application. We investigated effects of dietary bioactive components and biopolymer encapsulation on lipids’ metabolism in obese mice. Bio-active components could enhance the effect of body and adipose tissue weight reduction in obese mice models. Dietary bio-active compounds together with biopolymer encapsulated lipids showed a great reduction in serum triglycerides and cholesterol.