Neuroprotective and antioxidant effects of Metasequoia glyptostroboides leaf extract

Cited 0 time in scopus
Metadata Downloads
Title
Neuroprotective and antioxidant effects of Metasequoia glyptostroboides leaf extract
Author(s)
Seung Jae Lee; S Y Lee; S J Hur; Y I Bae; C H Jeong
Bibliographic Citation
Current Topics in Nutraceutical Research, vol. 14, no. 1, pp. 67-72
Publication Year
2016
Abstract
Extracts from the leaves of Metasequoia glyptostroboides (M. glyptostroboides) were investigated for antioxidant and neuroprotective effects in an attempt to further the development of novel pharmaceuticals. We demonstrated the antioxidant activities of these extracts using multiple methods, including the 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazoliumbromide cell viability and malondialdehyde assays; 2', 7'-dichlorofluorescein diacetate (DCF-DA) was used to detect and measure reactive oxygen species (ROS). These extracts effectively inhibited hydrogen peroxide-induced lipid peroxidation in neuronal PC12 cells by reducing intracellular ROS accumulation. High-performance liquid chromatography analysis revealed these extracts to contain a variety of known compounds (including rutin, quercitrin, myricetin, quercetin, kaempferol, gallic acid, epigallocatechin, epigallocatechin gallate, caffeic acid, and epicatechin gallate) in varying amounts. The extracts from M. glyptostroboides leaves exhibited a similar (and in some cases, more favorable) biological activity to that of ascorbic acid. The findings of this study suggested that M. glyptostroboides leaves have the potential to protect against hydrogen peroxide-induced damage and should be considered as a prospective functional food.
Keyword
Antioxidant activityMetasequoia glyptostroboidesMouse brain lipidNeuro-protective effectReactive oxygen species
ISSN
1540-7535
Publisher
New Century Health Publishers, Llc
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.