Tyrphostin A9 improves blastocyst development in porcine embryos through induction of dynamin-related protein 1-dependent mitochondrial fission

Cited 5 time in scopus
Metadata Downloads
Title
Tyrphostin A9 improves blastocyst development in porcine embryos through induction of dynamin-related protein 1-dependent mitochondrial fission
Author(s)
J H Ahn; H J Park; J W Kim; J Y Park; S Y Park; S G Yang; C H Kim; Seung-Bin YoonSun-Uk Kim; Kyu Tae Chang; D B Koo
Bibliographic Citation
Mitochondrion, vol. 35, pp. 80-86
Publication Year
2017
Abstract
Mitochondrial dynamics are associated with the development of porcine embryos. However, little is known about the effects of mitochondrial dynamics-related genes (Drp1 and pDrp1-Ser616) on early porcine embryo development. Here, we investigated the effect of Drp1-dependent mitochondrial fission signaling on the development of porcine embryos using the mitochondrial fission inducer, tyrphostin A9 (TA9). We determined that TA9 (1 μM) treated embryos were increased the mitochondrial functions, blastocyst development rate and quality, as well as decreased mitochondria-specific superoxide and mitochondrial apoptosis. Thus, TA9-induced appropriate mitochondrial fission improved the developmental competence via maintenance of a balance in mitochondrial dynamics in porcine embryo.
Keyword
Drp1Mitochondrial fissionMitochondrial functionPorcine embryoTyrphostin A9 (TA9)
ISSN
1567-7249
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.mito.2017.05.008
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Primate Resources Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.