Gain switching for a detection system to accommodate a newly developed MALDI-based quantification method

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Title
Gain switching for a detection system to accommodate a newly developed MALDI-based quantification method
Author(s)
S H Ahn; T Hyeon; M S Kim; Jeong Hee Moon
Bibliographic Citation
Journal of American Society for Mass Spectrometry, vol. 28, no. 9, pp. 1987-1990
Publication Year
2017
Abstract
In matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF), matrix-derived ions are routinely deflected away to avoid problems with ion detection. This, however, limits the use of a quantification method that utilizes the analyte-to-matrix ion abundance ratio. In this work, we will show that it is possible to measure this ratio by a minor instrumental modification of a simple form of MALDI-TOF. This involves detector gain switching. [Figure not available: see fulltext.].
Keyword
Detector gain switchingMALDI quantificationMALDI-TOF instrument
ISSN
1044-0305
Publisher
Amer Soc Mass Spectr
DOI
http://dx.doi.org/10.1007/s13361-017-1711-2
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
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