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- Conifer diterpene resin acids disrupt juvenile hormone-mediated endocrine regulation in the Indian meal moth Plodia interpunctella
- Hyun Woo Oh; Chan Seok Yun; Jun Hyoung Jeon; Ji Ae Kim; Doo-Sang Park; Hyung Won Ryu; Sei-Ryang Oh; H H Song; Y Shin; C S Jung; Sang Woon Shin
- Bibliographic Citation
- Journal of Chemical Ecology, vol. 43, no. 7, pp. 703-711
- Publication Year
- Diterpene resin acids (DRAs) are important components of oleoresin and greatly contribute to the defense strategies of conifers against herbivorous insects. In the present study, we determined that DRAs function as insect juvenile hormone (JH) antagonists that interfere with the juvenile hormone-mediated binding of the JH receptor Methoprene-tolerant (Met) and steroid receptor coactivator (SRC). Using a yeast two-hybrid system transformed with Met and SRC from the Indian meal moth Plodia interpunctella, we tested the interfering activity of 3704 plant extracts against JH III-mediated Met-SRC binding. Plant extracts from conifers, especially members of the Pinaceae, exhibited strong interfering activity, and four active interfering DRAs (7α-dehydroabietic acid, 7-oxodehydroabietic acid, dehydroabietic acid, and sandaracopimaric acid) were isolated from roots of the Japanese pine Pinus densiflora. The four isolated DRAs, along with abietic acid, disrupted the juvenile hormone-mediated binding of P. interpunctella Met and SRC, although only 7-oxodehydroabietic acid disrupted larval development. These results demonstrate that DRAs may play a defensive role against herbivorous insects via insect endocrine-disrupting activity.
- Diterpene resin acid; Herbivore; Insect development; Juvenile hormone; Juvenile hormone antagonist; Plant defense; Terpenes
- Appears in Collections:
- Division of Bio Technology Innovation > Core Facility Management Center > 1. Journal Articles
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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