Conifer diterpene resin acids disrupt juvenile hormone-mediated endocrine regulation in the Indian meal moth Plodia interpunctella

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Title
Conifer diterpene resin acids disrupt juvenile hormone-mediated endocrine regulation in the Indian meal moth Plodia interpunctella
Author(s)
Hyun Woo OhChan Seok Yun; Jun Hyoung Jeon; Ji Ae KimDoo-Sang ParkHyung Won RyuSei-Ryang Oh; H H Song; Y Shin; C S Jung; Sang Woon Shin
Bibliographic Citation
Journal of Chemical Ecology, vol. 43, no. 7, pp. 703-711
Publication Year
2017
Abstract
Diterpene resin acids (DRAs) are important components of oleoresin and greatly contribute to the defense strategies of conifers against herbivorous insects. In the present study, we determined that DRAs function as insect juvenile hormone (JH) antagonists that interfere with the juvenile hormone-mediated binding of the JH receptor Methoprene-tolerant (Met) and steroid receptor coactivator (SRC). Using a yeast two-hybrid system transformed with Met and SRC from the Indian meal moth Plodia interpunctella, we tested the interfering activity of 3704 plant extracts against JH III-mediated Met-SRC binding. Plant extracts from conifers, especially members of the Pinaceae, exhibited strong interfering activity, and four active interfering DRAs (7α-dehydroabietic acid, 7-oxodehydroabietic acid, dehydroabietic acid, and sandaracopimaric acid) were isolated from roots of the Japanese pine Pinus densiflora. The four isolated DRAs, along with abietic acid, disrupted the juvenile hormone-mediated binding of P. interpunctella Met and SRC, although only 7-oxodehydroabietic acid disrupted larval development. These results demonstrate that DRAs may play a defensive role against herbivorous insects via insect endocrine-disrupting activity.
Keyword
Diterpene resin acidHerbivoreInsect developmentJuvenile hormoneJuvenile hormone antagonistPlant defenseTerpenes
ISSN
0098-0331
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s10886-017-0861-9
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > Core Facility Management Center > 1. Journal Articles
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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