The fungal metabolite brefeldin A inhibits Dvl2-Plk1-dependent primary cilium disassembly

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dc.contributor.authorUijeong Lee-
dc.contributor.authorSun Ok Kim-
dc.contributor.authorJeong Ah Hwang-
dc.contributor.authorJae-Hyuk Jang-
dc.contributor.authorSangkeun Son-
dc.contributor.authorIn Ja Ryoo-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorKyung Ho Lee-
dc.date.accessioned2018-01-11-
dc.date.available2018-01-11-
dc.date.issued2017-
dc.identifier.issn10168478-
dc.identifier.uri10.14348/molcells.2017.0032ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/17397-
dc.description.abstractThe primary cilium is a non-motile microtubule-based organelle that protrudes from the surface of most human cells and works as a cellular antenna to accept extracellular signals. Primary cilia assemble from the basal body during the resting stage (G0 phase) and simultaneously disassemble with cell cycle re-entry. Defective control of assembly or disassembly causes diverse human diseases including ciliopathy and cancer. To identify the effective compounds for studying primary cilium disassembly, we have screened 297 natural compounds and identified 18 and 17 primary cilium assembly and disassembly inhibitors, respectively. Among them, the application of KY-0120, identified as Brefeldin A, disturbed Dvl2- Plk1-mediated cilium disassembly via repression of the interaction of CK1ε-Dvl2 and the expression of Plk1 mRNA. Therefore, our study may suggest useful compounds for studying the cellular mechanism of primary cilium disassembly to prevent ciliopathy and cancer-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleThe fungal metabolite brefeldin A inhibits Dvl2-Plk1-dependent primary cilium disassembly-
dc.title.alternativeThe fungal metabolite brefeldin A inhibits Dvl2-Plk1-dependent primary cilium disassembly-
dc.typeArticle-
dc.citation.titleMolecules and Cells-
dc.citation.number6-
dc.citation.endPage409-
dc.citation.startPage401-
dc.citation.volume40-
dc.contributor.affiliatedAuthorUijeong Lee-
dc.contributor.affiliatedAuthorSun Ok Kim-
dc.contributor.affiliatedAuthorJeong Ah Hwang-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.affiliatedAuthorSangkeun Son-
dc.contributor.affiliatedAuthorIn Ja Ryoo-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorKyung Ho Lee-
dc.contributor.alternativeName이의정-
dc.contributor.alternativeName김선옥-
dc.contributor.alternativeName황정아-
dc.contributor.alternativeName장재혁-
dc.contributor.alternativeName손상근-
dc.contributor.alternativeName류인자-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName이경호-
dc.identifier.bibliographicCitationMolecules and Cells, vol. 40, no. 6, pp. 401-409-
dc.identifier.doi10.14348/molcells.2017.0032-
dc.subject.keywordBrefeldin A-
dc.subject.keywordDvl2-
dc.subject.keywordInhibitor-
dc.subject.keywordPlk1-
dc.subject.keywordPrimary cilium disassembly-
dc.subject.localBrefeldin A-
dc.subject.localDvl2-
dc.subject.localInhibitor-
dc.subject.localInhibitors-
dc.subject.localinhibitor-
dc.subject.localinhibitors-
dc.subject.localPlk1-
dc.subject.localPrimary cilium disassembly-
dc.description.journalClassY-
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