Acyclic triterpenoids from Alpinia katsumadai inhibit IL-6-Induced STAT3 activation

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dc.contributor.authorHyun Jae Jang-
dc.contributor.authorSeung Jae Lee-
dc.contributor.authorSoyoung Lee-
dc.contributor.authorKyungsook Jung-
dc.contributor.authorSeung Woong Lee-
dc.contributor.authorMun Chual Rho-
dc.date.accessioned2018-01-11-
dc.date.available2018-01-11-
dc.date.issued2017-
dc.identifier.issn14203049-
dc.identifier.uri10.3390/molecules22101611ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/17448-
dc.description.abstractThe seeds of Alpinia katsumadai yielded two new acyclic triterpenoids, 2,3,6,22,23 -pentahydroxy -2,6,11,15,19,23-hexamethyl-tetracosa-7,10,14,18-tetraene (3) and 2,3,6,22,23 -pentahydroxy-2,10,15,19,23-hexamethyl-7-methylenetetracosa-10,14,18-triene (4), as well as two known compounds, 2,3,22,23-tertrahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14,18-tetraene (1) and 2,3,5,22,23-pentahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14,18-tetraene (2). The absolute configurations of 2 and 3, which were determined by means of a modified Mosher’s method, are suggested as (3R; 5S; 22R) and (3R; 22R), respectively. Compounds 1?4 inhibited IL-6-induced JAK2/STAT3 activity in a dose-dependent fashion, with IC50 values of 0.67, 0.71, 2.18, and 2.99 μM. Moreover, IL-6-stimulated phosphorylation of STAT3 was significantly suppressed in U266 cells by the administration of A. katsumadai EtOH extract and Compounds 1 and 2. These results suggest that major phytochemicals, Compounds 1 and 2, obtained from A. katsumadai may be useful candidates for designing new IL-6 inhibitors as anti-inflammatory agents-
dc.publisherMDPI-
dc.titleAcyclic triterpenoids from Alpinia katsumadai inhibit IL-6-Induced STAT3 activation-
dc.title.alternativeAcyclic triterpenoids from Alpinia katsumadai inhibit IL-6-Induced STAT3 activation-
dc.typeArticle-
dc.citation.titleMolecules-
dc.citation.number10-
dc.citation.endPage1611-
dc.citation.startPage1611-
dc.citation.volume22-
dc.contributor.affiliatedAuthorHyun Jae Jang-
dc.contributor.affiliatedAuthorSeung Jae Lee-
dc.contributor.affiliatedAuthorSoyoung Lee-
dc.contributor.affiliatedAuthorKyungsook Jung-
dc.contributor.affiliatedAuthorSeung Woong Lee-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.alternativeName장현재-
dc.contributor.alternativeName이승재-
dc.contributor.alternativeName이소영-
dc.contributor.alternativeName정경숙-
dc.contributor.alternativeName이승웅-
dc.contributor.alternativeName노문철-
dc.identifier.bibliographicCitationMolecules, vol. 22, no. 10, pp. 1611-1611-
dc.identifier.doi10.3390/molecules22101611-
dc.subject.keywordAcyclic triterpenoids-
dc.subject.keywordAlpinia katsumadai-
dc.subject.keywordIL-6-
dc.subject.keywordInflammation-
dc.subject.keywordSTAT3-
dc.subject.localAcyclic triterpenoids-
dc.subject.localAlpinia katsumadai-
dc.subject.localInterleukin-6-
dc.subject.localInterleukin-6 (IL-6)-
dc.subject.localIL-6-
dc.subject.localIL6-
dc.subject.localIl-6-
dc.subject.localinterleukin-6-
dc.subject.localinterleukin-6 (IL-6)-
dc.subject.localInflammation-
dc.subject.localinflammation-
dc.subject.localSTAT 3-
dc.subject.localSTAT3-
dc.subject.localSignal transducer and activator of transcription-
dc.subject.localSignal transducer and activator of transcription 3-
dc.subject.localSignal transducer and activator of transcription 3 (STAT3)-
dc.subject.localSignal transducer and activator of transcription 3 (Stat3)-
dc.subject.localSignal transducer and activator of transcription factor 3 (STAT3)-
dc.subject.localStat3-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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