Ottogi inhibits Wnt/β-catenin signaling by regulating cell membrane trafficking of Frizzled8

Cited 2 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorH T Kim-
dc.contributor.authorM S Lee-
dc.contributor.authorY M Jeong-
dc.contributor.authorH Ro-
dc.contributor.authorD I Kim-
dc.contributor.authorY H Shin-
dc.contributor.authorJ E Kim-
dc.contributor.authorK S Hwang-
dc.contributor.authorJ H Choi-
dc.contributor.authorM Bahn-
dc.contributor.authorJeong Ju Lee-
dc.contributor.authorS H Lee-
dc.contributor.authorY K Bae-
dc.contributor.authorJ S Lee-
dc.contributor.authorJ K Choi-
dc.contributor.authorNam-Soon Kim-
dc.contributor.authorC Y Yeo-
dc.contributor.authorC H Kim-
dc.date.accessioned2018-01-11-
dc.date.available2018-01-11-
dc.date.issued2017-
dc.identifier.issn20452322-
dc.identifier.uri10.1038/s41598-017-13429-6ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/17476-
dc.description.abstractWnt signaling controls critical developmental processes including tissue/body patterning. Here we report the identification of a novel regulator of Wnt signaling, OTTOGI (OTG), isolated from a large-scale expression screening of human cDNAs in zebrafish embryos. Overexpression of OTG in zebrafish embryos caused dorso-Anteriorized phenotype, inhibited the expression of Wnt target genes, and prevented nuclear accumulation of β-catenin. Conversely, knockdown of zebrafish otg using specific antisense morpholino promoted nuclear accumulation of β-catenin and caused ventralization. However, OTG failed to rescue headless-like phenotype induced by inhibition of GSK-3β activity, suggesting that OTG acts upstream of GSK-3β. OTG bound specifically to Frizzled8 (Fz8) receptor and caused retention of Fz8 in the endoplasmic reticulum possibly by preventing N-linked glycosylation of Fz8. Taken together, our data indicate that OTG functions as a novel negative regulator of Wnt signaling during development by the modulation of cell surface expression of Fz receptor.-
dc.publisherSpringer-Nature Pub Group-
dc.titleOttogi inhibits Wnt/β-catenin signaling by regulating cell membrane trafficking of Frizzled8-
dc.title.alternativeOttogi inhibits Wnt/β-catenin signaling by regulating cell membrane trafficking of Frizzled8-
dc.typeArticle-
dc.citation.titleScientific Reports-
dc.citation.number0-
dc.citation.endPage13278-
dc.citation.startPage13278-
dc.citation.volume7-
dc.contributor.affiliatedAuthorJeong Ju Lee-
dc.contributor.affiliatedAuthorNam-Soon Kim-
dc.contributor.alternativeName김현택-
dc.contributor.alternativeName이미선-
dc.contributor.alternativeName정윤미-
dc.contributor.alternativeName노현주-
dc.contributor.alternativeName김동일-
dc.contributor.alternativeName신용환-
dc.contributor.alternativeName김지은-
dc.contributor.alternativeName황규석-
dc.contributor.alternativeName최정화-
dc.contributor.alternativeName반민진-
dc.contributor.alternativeName이정주-
dc.contributor.alternativeName이상-
dc.contributor.alternativeName배영기-
dc.contributor.alternativeName이진수-
dc.contributor.alternativeName최중국-
dc.contributor.alternativeName김남순-
dc.contributor.alternativeName여창열-
dc.contributor.alternativeName김철희-
dc.identifier.bibliographicCitationScientific Reports, vol. 7, pp. 13278-13278-
dc.identifier.doi10.1038/s41598-017-13429-6-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
Files in This Item:

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.