MR assessment of acute pathologic process after myocardial infarction in a permanent ligation mouse model: role of magnetic nanoparticle-contrasted MRI

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Title
MR assessment of acute pathologic process after myocardial infarction in a permanent ligation mouse model: role of magnetic nanoparticle-contrasted MRI
Author(s)
C Park; E H Park; Jongeun Kang; J Zaheer; Hee Gu LeeChul Ho Lee; K Chang; K S Hong
Bibliographic Citation
Contrast Media & Molecular Imaging, vol. 2017, pp. 2870802-2870802
Publication Year
2017
Abstract
We evaluated the relationship between myocardial infarct size and inflammatory response using cardiac magnetic resonance imaging (CMR) in an acute myocardial infarction (AMI) mouse model. Myocardial infarction (MI) was induced in 14 mice by permanent ligation of the left anterior descending artery. Late gadolinium enhancement (LGE), manganese-enhanced MRI (MEMRI), and magnetofluorescent nanoparticle MRI (MNP-MRI) were performed 1, 2, and 3 days after MI, respectively. The size of the enhanced lesion was quantitatively determined using Otsu's thresholding method in area-based and sector-based approaches and was compared statistically. Linear correlation between the enhanced lesion sizes was evaluated by Pearson's correlation coefficients. Differences were compared using Bland-Altman analysis. The size of the inflammatory area determined by MNP-MRI (57.1 ± 10.1%) was significantly larger than that of the infarct area measured by LGE (40.8 ± 11.7%, P<0.0001) and MEMRI (44.1 ± 14.9%, P<0.0001). There were significant correlations between the sizes of the infarct and inflammatory lesions (MNP-MRI versus LGE: r=0.3418, P=0.0099; MNP-MRI versus MEMRI: r=0.4764, P=0.0002). MNP-MRI provides information about inflammatory responses in a mouse model of AMI. Thus, MNP-MRI associated with LGE and MEMRI may play an important role in monitoring the disease progression in MI. ⓒ 2017 Cheongsoo Park et al.
ISSN
1555-4309
Publisher
Hindawi Ltd
Full Text Link
http://dx.doi.org/10.1155/2017/2870802
Type
Article
Appears in Collections:
Division of A.I. & Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > 1. Journal Articles
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