Molecular mechanisms and therapeutic interventions in sarcopenia

Cited 0 time in scopus
Metadata Downloads
Title
Molecular mechanisms and therapeutic interventions in sarcopenia
Author(s)
Sung Sup ParkEun Soo KwonKi Sun Kwon
Bibliographic Citation
Osteoporosis and Sarcopenia, vol. 3, no. 3, pp. 117-122
Publication Year
2017
Abstract
Sarcopenia is the degenerative loss of muscle mass and function with aging. Recently sarcopenia was recognized as a clinical disease by the International Classification of Disease, 10th revision, Clinical Modification. An imbalance between protein synthesis and degradation causes a gradual loss of muscle mass, resulting in a decline of muscle function as a progress of sarcopenia. Many mechanisms involved in the onset of sarcopenia include age-related factors as well as activity-, disease-, and nutrition-related factors. The stage of sarcopenia reflecting the severity of conditions assists clinical management of sarcopenia. It is important that systemic descriptions of the disease conditions include age, sex, and other environmental risk factors as well as levels of physical function. To develop a new therapeutic intervention needed is the detailed understanding of molecular and cellular mechanisms by which apoptosis, autophagy, atrophy, and hypertrophy occur in the muscle stem cells, myotubes, and/or neuromuscular junction. The new strategy to managing sarcopenia will be signal-modulating small molecules, natural compounds, repurposing of old drugs, and muscle-specific microRNAs.
Keyword
MechanismsTherapySkeletalAgingSarcopenia
ISSN
2405-5255
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.1016/j.afos.2017.08.098
Type
Article
Appears in Collections:
Division of Research on National Challenges > Aging Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.