DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jae Won Lee | - |
dc.contributor.author | Hyung Won Ryu | - |
dc.contributor.author | So Yeon Park | - |
dc.contributor.author | Hyun Ah Park | - |
dc.contributor.author | Ok-Kyoung Kwon | - |
dc.contributor.author | Heung Joo Yuk | - |
dc.contributor.author | K K Shrestha | - |
dc.contributor.author | M Park | - |
dc.contributor.author | Jung Hee Kim | - |
dc.contributor.author | Sangwoo Lee | - |
dc.contributor.author | Sei-Ryang Oh | - |
dc.contributor.author | Kyung Seop Ahn | - |
dc.date.accessioned | 2018-01-11T02:53:27Z | - |
dc.date.available | 2018-01-11T02:53:27Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.uri | 10.3892/ijmm.2017.3178 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/17545 | - |
dc.description.abstract | Neem (Azadirachta indica A. Juss.) leaf has been reported to exert anti-inflammatory, antibacterial and antioxidant effects. The purpose of this study was to investigate the protective effects of neem leaf extract (NLE) against cigarette smoke (CS)- and lipopolysaccharide (LPS)-induced pulmonary inflammation. Treatment with NLE significantly attenuated the infiltration of inflammatory cells, such as neutrophils and macrophages in bronchoalveolar lavage fluid (BALF). NLE also reduced the production of reactive oxygen species and the activity of neutrophil elastase in BALF. Moreover, NLE attenuated the release of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in BALF. NLE inhibited the recruitment of inflammatory cells and the expression of monocyte chemoattractant protein-1 (MCP-1) in the lungs of mice with CS- and LPS-induced pulmonary inflammation. NLE also decreased the expression of inducible nitric oxide synthase (iNOS) in the lungs of the mice CS- and LPS-induced pulmonary inflammation. Furthermore, treatment with NLE significantly attenuated the activation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in the lungs mice exposed to CS and LPS. NLE also inhibited the phosphorylation of nuclear factor (NF)-κB and inhibitor of NF-κB (IκB) in the lungs of mice expose to CS and LPS. These findings thus suggest that NLE has potential for use in the treatment of chronic obstructive pulmonary disease | - |
dc.publisher | Spandidos Publ Ltd | - |
dc.title | Protective effects of neem (Azadirachta indica A. Juss.) leaf extract against cigarette smoke- and lipopolysaccharide-induced pulmonary inflammation | - |
dc.title.alternative | Protective effects of neem (Azadirachta indica A. Juss.) leaf extract against cigarette smoke- and lipopolysaccharide-induced pulmonary inflammation | - |
dc.type | Article | - |
dc.citation.title | International Journal of Molecular Medicine | - |
dc.citation.number | 6 | - |
dc.citation.endPage | 1940 | - |
dc.citation.startPage | 1932 | - |
dc.citation.volume | 40 | - |
dc.contributor.affiliatedAuthor | Jae Won Lee | - |
dc.contributor.affiliatedAuthor | Hyung Won Ryu | - |
dc.contributor.affiliatedAuthor | So Yeon Park | - |
dc.contributor.affiliatedAuthor | Hyun Ah Park | - |
dc.contributor.affiliatedAuthor | Ok-Kyoung Kwon | - |
dc.contributor.affiliatedAuthor | Heung Joo Yuk | - |
dc.contributor.affiliatedAuthor | Jung Hee Kim | - |
dc.contributor.affiliatedAuthor | Sangwoo Lee | - |
dc.contributor.affiliatedAuthor | Sei-Ryang Oh | - |
dc.contributor.affiliatedAuthor | Kyung Seop Ahn | - |
dc.contributor.alternativeName | 이재원 | - |
dc.contributor.alternativeName | 류형원 | - |
dc.contributor.alternativeName | 박소연 | - |
dc.contributor.alternativeName | 박현아 | - |
dc.contributor.alternativeName | 권옥경 | - |
dc.contributor.alternativeName | 육흥주 | - |
dc.contributor.alternativeName | Shrestha | - |
dc.contributor.alternativeName | 박민우 | - |
dc.contributor.alternativeName | 김정희 | - |
dc.contributor.alternativeName | 이상우 | - |
dc.contributor.alternativeName | 오세량 | - |
dc.contributor.alternativeName | 안경섭 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Medicine, vol. 40, no. 6, pp. 1932-1940 | - |
dc.identifier.doi | 10.3892/ijmm.2017.3178 | - |
dc.subject.keyword | Chronic obstructive pulmonary disease | - |
dc.subject.keyword | Cigarette smoke | - |
dc.subject.keyword | Lipopolysaccharide | - |
dc.subject.keyword | Mitogen-activated protein kinases | - |
dc.subject.keyword | Neem | - |
dc.subject.keyword | Neutrophil | - |
dc.subject.keyword | Nuclear factor-κB | - |
dc.subject.local | Chronic obstructive pulmonary disease (COPD) | - |
dc.subject.local | Chronic obstructive pulmonary disease | - |
dc.subject.local | chronic obstructive pulmonary disease | - |
dc.subject.local | cigarette smoke | - |
dc.subject.local | Cigarette smoke | - |
dc.subject.local | lipopolysaccharide (LPS) | - |
dc.subject.local | Lipopolysaccharide | - |
dc.subject.local | lipopolysaccharide | - |
dc.subject.local | Lipopolysaccharide (LPS) | - |
dc.subject.local | Lipopolysaccharides | - |
dc.subject.local | mitogen-activated protein kinase | - |
dc.subject.local | Mitogen activated protein kinase | - |
dc.subject.local | Mitogen-activated protein (MAP) kinase | - |
dc.subject.local | mitogen-activated protein kinases | - |
dc.subject.local | Mitogen-activated protein kinase (MAPK) | - |
dc.subject.local | Mitogen-activated protein kinase | - |
dc.subject.local | Mitogenactivated protein kinase | - |
dc.subject.local | mitogen activated protein kinase | - |
dc.subject.local | Mitogen-activated protein kinases (MAPKs) | - |
dc.subject.local | Mitogen-acti-vated protein kinase | - |
dc.subject.local | Mitogen-activated protein kinases | - |
dc.subject.local | Neem | - |
dc.subject.local | Neutrophils | - |
dc.subject.local | Neutrophil | - |
dc.subject.local | neutrophil | - |
dc.subject.local | neutrophils | - |
dc.subject.local | Nuclear factor-kappa B | - |
dc.subject.local | nuclear factor κB | - |
dc.subject.local | Nf-κb | - |
dc.subject.local | NF-kB | - |
dc.subject.local | nuclear factor kappa B | - |
dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
dc.subject.local | NF-kappaB | - |
dc.subject.local | Nuclear factor-κb | - |
dc.subject.local | NF-κ B | - |
dc.subject.local | NF-κB | - |
dc.subject.local | NF-kappa B | - |
dc.subject.local | Nuclear factor κB (NF-κB) | - |
dc.subject.local | Nuclear factor κB | - |
dc.subject.local | NFκB | - |
dc.subject.local | Nf-κB | - |
dc.subject.local | Nuclear factor-κB | - |
dc.subject.local | nuclear factorκB | - |
dc.subject.local | Nuclear factor (NF)-κB | - |
dc.subject.local | Nuclear factor kappa B | - |
dc.subject.local | nuclear factor-κB | - |
dc.subject.local | NF-ΚB | - |
dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
dc.subject.local | Nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB | - |
dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
dc.subject.local | NFkappaB | - |
dc.subject.local | Nuclear factor kappaB | - |
dc.description.journalClass | Y | - |
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