Protective effects of neem (Azadirachta indica A. Juss.) leaf extract against cigarette smoke- and lipopolysaccharide-induced pulmonary inflammation

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dc.contributor.authorJae Won Lee-
dc.contributor.authorHyung Won Ryu-
dc.contributor.authorSo Yeon Park-
dc.contributor.authorHyun Ah Park-
dc.contributor.authorOk-Kyoung Kwon-
dc.contributor.authorHeung Joo Yuk-
dc.contributor.authorK K Shrestha-
dc.contributor.authorM Park-
dc.contributor.authorJung Hee Kim-
dc.contributor.authorSangwoo Lee-
dc.contributor.authorSei-Ryang Oh-
dc.contributor.authorKyung Seop Ahn-
dc.date.accessioned2018-01-11T02:53:27Z-
dc.date.available2018-01-11T02:53:27Z-
dc.date.issued2017-
dc.identifier.issn1107-3756-
dc.identifier.uri10.3892/ijmm.2017.3178ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/17545-
dc.description.abstractNeem (Azadirachta indica A. Juss.) leaf has been reported to exert anti-inflammatory, antibacterial and antioxidant effects. The purpose of this study was to investigate the protective effects of neem leaf extract (NLE) against cigarette smoke (CS)- and lipopolysaccharide (LPS)-induced pulmonary inflammation. Treatment with NLE significantly attenuated the infiltration of inflammatory cells, such as neutrophils and macrophages in bronchoalveolar lavage fluid (BALF). NLE also reduced the production of reactive oxygen species and the activity of neutrophil elastase in BALF. Moreover, NLE attenuated the release of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in BALF. NLE inhibited the recruitment of inflammatory cells and the expression of monocyte chemoattractant protein-1 (MCP-1) in the lungs of mice with CS- and LPS-induced pulmonary inflammation. NLE also decreased the expression of inducible nitric oxide synthase (iNOS) in the lungs of the mice CS- and LPS-induced pulmonary inflammation. Furthermore, treatment with NLE significantly attenuated the activation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in the lungs mice exposed to CS and LPS. NLE also inhibited the phosphorylation of nuclear factor (NF)-κB and inhibitor of NF-κB (IκB) in the lungs of mice expose to CS and LPS. These findings thus suggest that NLE has potential for use in the treatment of chronic obstructive pulmonary disease-
dc.publisherSpandidos Publ Ltd-
dc.titleProtective effects of neem (Azadirachta indica A. Juss.) leaf extract against cigarette smoke- and lipopolysaccharide-induced pulmonary inflammation-
dc.title.alternativeProtective effects of neem (Azadirachta indica A. Juss.) leaf extract against cigarette smoke- and lipopolysaccharide-induced pulmonary inflammation-
dc.typeArticle-
dc.citation.titleInternational Journal of Molecular Medicine-
dc.citation.number6-
dc.citation.endPage1940-
dc.citation.startPage1932-
dc.citation.volume40-
dc.contributor.affiliatedAuthorJae Won Lee-
dc.contributor.affiliatedAuthorHyung Won Ryu-
dc.contributor.affiliatedAuthorSo Yeon Park-
dc.contributor.affiliatedAuthorHyun Ah Park-
dc.contributor.affiliatedAuthorOk-Kyoung Kwon-
dc.contributor.affiliatedAuthorHeung Joo Yuk-
dc.contributor.affiliatedAuthorJung Hee Kim-
dc.contributor.affiliatedAuthorSangwoo Lee-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.alternativeName이재원-
dc.contributor.alternativeName류형원-
dc.contributor.alternativeName박소연-
dc.contributor.alternativeName박현아-
dc.contributor.alternativeName권옥경-
dc.contributor.alternativeName육흥주-
dc.contributor.alternativeNameShrestha-
dc.contributor.alternativeName박민우-
dc.contributor.alternativeName김정희-
dc.contributor.alternativeName이상우-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName안경섭-
dc.identifier.bibliographicCitationInternational Journal of Molecular Medicine, vol. 40, no. 6, pp. 1932-1940-
dc.identifier.doi10.3892/ijmm.2017.3178-
dc.subject.keywordChronic obstructive pulmonary disease-
dc.subject.keywordCigarette smoke-
dc.subject.keywordLipopolysaccharide-
dc.subject.keywordMitogen-activated protein kinases-
dc.subject.keywordNeem-
dc.subject.keywordNeutrophil-
dc.subject.keywordNuclear factor-κB-
dc.subject.localChronic obstructive pulmonary disease (COPD)-
dc.subject.localChronic obstructive pulmonary disease-
dc.subject.localchronic obstructive pulmonary disease-
dc.subject.localcigarette smoke-
dc.subject.localCigarette smoke-
dc.subject.locallipopolysaccharide (LPS)-
dc.subject.localLipopolysaccharide-
dc.subject.locallipopolysaccharide-
dc.subject.localLipopolysaccharide (LPS)-
dc.subject.localLipopolysaccharides-
dc.subject.localmitogen-activated protein kinase-
dc.subject.localMitogen activated protein kinase-
dc.subject.localMitogen-activated protein (MAP) kinase-
dc.subject.localmitogen-activated protein kinases-
dc.subject.localMitogen-activated protein kinase (MAPK)-
dc.subject.localMitogen-activated protein kinase-
dc.subject.localMitogenactivated protein kinase-
dc.subject.localmitogen activated protein kinase-
dc.subject.localMitogen-activated protein kinases (MAPKs)-
dc.subject.localMitogen-acti-vated protein kinase-
dc.subject.localMitogen-activated protein kinases-
dc.subject.localNeem-
dc.subject.localNeutrophils-
dc.subject.localNeutrophil-
dc.subject.localneutrophil-
dc.subject.localneutrophils-
dc.subject.localNuclear factor-kappa B-
dc.subject.localnuclear factor κB-
dc.subject.localNf-κb-
dc.subject.localNF-kB-
dc.subject.localnuclear factor kappa B-
dc.subject.localNF-κB (nuclear factor kappa-B)-
dc.subject.localNF-kappaB-
dc.subject.localNuclear factor-κb-
dc.subject.localNF-κ B-
dc.subject.localNF-κB-
dc.subject.localNF-kappa B-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localNuclear factor κB-
dc.subject.localNFκB-
dc.subject.localNf-κB-
dc.subject.localNuclear factor-κB-
dc.subject.localnuclear factorκB-
dc.subject.localNuclear factor (NF)-κB-
dc.subject.localNuclear factor kappa B-
dc.subject.localnuclear factor-κB-
dc.subject.localNF-ΚB-
dc.subject.localNuclear factor-kappa B (NF-κB)-
dc.subject.localNuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB (NF-κB)-
dc.subject.localNFkappaB-
dc.subject.localNuclear factor kappaB-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > International Biological Material Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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