Effects of Bambusa tulda on the proliferation of human stem cells

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Title
Effects of Bambusa tulda on the proliferation of human stem cells
Author(s)
H Lee; M S Uddin; Sang Woo LeeSangho Choi; J B Park
Bibliographic Citation
Experimental and Therapeutic Medicine, vol. 14, no. 6, pp. 5696-5702
Publication Year
2017
Abstract
To date, the effects of Bambusa tulda on stem cells have not been thoroughly assessed. The present study aimed to evaluate the effects of Bambusa tulda extract on the morphology and proliferative potential of human mesenchymal stem cells derived from the gingiva. The stem cells were cultured in a growth medium in the presence of Bambusa tulda methanolic extract (BBT) at concentrations ranging from 0.001 to 1%. Evaluation of cell morphology and cellular proliferation as well as immunofluorescent assays for collagen I were performed on days 1, 3, 5 and 7. Stem cells in the control group displayed a fibroblast-like morphology, and BBT treatment did not produce any noticeable morphological changes. However, application of 1% BBT produced a significant increase in cell proliferation. BBT, particularly at the concentration of 1%, also caused a noticeable increase of collagen I expression at day 1 and day 3. Based on these findings, it was concluded that BBT exerted beneficial effects on the proliferation of mesenchymal stem cells and enhanced collagen I expression at early time points.
Keyword
BambusaCell proliferationCell survivalHerbal medicineMedicinal plantsStem cells
ISSN
1792-0981
Publisher
Spandidos Publ Ltd
DOI
http://dx.doi.org/10.3892/etm.2017.5276
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > International Biological Material Research Center > 1. Journal Articles
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