Rescuing p53 from mdm2 by a pre-structured motif in intrinsically unfolded SUMO specific protease 4

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Title
Rescuing p53 from mdm2 by a pre-structured motif in intrinsically unfolded SUMO specific protease 4
Author(s)
Do-Hyoung Kim; Chewook Lee; Bom Kim; Si-Hyung Lee; Kyou Hoon Han
Bibliographic Citation
BMB Reports, vol. 50, no. 10, pp. 485-486
Publication Year
2017
Abstract
Many intrinsically unstructured/unfolded proteins (IUPs) contain transient local secondary structures even though they are "unstructured" in a tertiary sense. These local secondary structures are named "pre-structured motifs (PreSMos)" and in fact are the specificity determinants for IUP-target binding, i.e., the active sites in IUPs. Using high-resolution NMR we have delineated a PreSMo active site in the intrinsically unfolded mid-domain (residues 201-300) of SUMO-specific protease 4 (SUSP4). This 29-residue motif which we termed a p53 rescue motif can protect p53 from mdm2 quenching by binding to the p53-helix binding pocket in mdm2(3-109). Our work demonstrates that the PreSMo approach is quite effective in providing a structural rationale for interactions of p53-mdm2- SUSP4 and opens a novel avenue for designing mdm2- inhibiting anticancer compounds.
Keyword
Mdm2p53PreSMoSUSP4IUP
ISSN
1225-8687
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.5483/BMBRep.2017.50.10.131
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
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