Opa-interacting protein 5 modulates docetaxel-induced cell death via regulation of mitophagy in gastric cancer

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dc.contributor.authorTae Woo Kim-
dc.contributor.authorSeon-Jin Lee-
dc.contributor.authorYoung-Jun Park-
dc.contributor.authorSang Yoon Park-
dc.contributor.authorByung Moo Oh-
dc.contributor.authorYun Sun Park-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorY H Lee-
dc.contributor.authorHee Jun Cho-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorYong Kyung Choe-
dc.contributor.authorHee Gu Lee-
dc.date.accessioned2018-01-11T02:53:36Z-
dc.date.available2018-01-11T02:53:36Z-
dc.date.issued2017-
dc.identifier.issn1010-4283-
dc.identifier.uri10.1177/1010428317733985ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/17572-
dc.description.abstractDamage to mitochondria induces mitophagy, a cellular process that is gaining interest for its therapeutic relevance to a variety of human diseases. However, the mechanism underlying mitochondrial depolarization and clearance in mitophagy remains poorly understood. We previously reported that mitochondria-induced cell death was caused by knockdown of Neisseria gonorrhoeae opacity-associated-interacting protein 5 in gastric cancer. In this study, we show that Neisseria gonorrhoeae opacity-associated-interacting protein 5 loss and gain of function modulates mitophagy induced by treatment with docetaxel, a chemotherapy drug for gastric cancer. The activation of mitophagy by Neisseria gonorrhoeae opacity-associated-interacting protein 5 overexpression promoted cell survival, preventing docetaxel-induced mitochondrial clearance. Conversely, short interfering RNA-mediated knockdown of Neisseria gonorrhoeae opacity-associated-interacting protein 5 accelerated docetaxel-induced apoptosis while increasing mitochondrial depolarization, reactive oxygen species, and endoplasmic reticulum stress and decreasing adenosine triphosphate production. We also found that the mitochondrial outer membrane proteins mitofusin 2 and phosphatase and tensin homolog-induced putative kinase 1 colocalized with Neisseria gonorrhoeae opacity-associated-interacting protein 5 in mitochondria and that mitofusin 2 knockdown altered Neisseria gonorrhoeae opacity-associated-interacting protein 5 expression. These findings indicate that Neisseria gonorrhoeae opacity-associated-interacting protein 5 modulates docetaxel-induced mitophagic cell death and therefore suggest that this protein comprises a potential therapeutic target for gastric cancer treatment-
dc.publisherSpringer Verlag (Germany)ko
dc.titleOpa-interacting protein 5 modulates docetaxel-induced cell death via regulation of mitophagy in gastric cancer-
dc.title.alternativeOpa-interacting protein 5 modulates docetaxel-induced cell death via regulation of mitophagy in gastric cancer-
dc.typeArticle-
dc.citation.titleTumor Biology-
dc.citation.number10-
dc.citation.endPage13-
dc.citation.startPage1-
dc.citation.volume39-
dc.contributor.affiliatedAuthorTae Woo Kim-
dc.contributor.affiliatedAuthorSeon-Jin Lee-
dc.contributor.affiliatedAuthorYoung-Jun Park-
dc.contributor.affiliatedAuthorSang Yoon Park-
dc.contributor.affiliatedAuthorByung Moo Oh-
dc.contributor.affiliatedAuthorYun Sun Park-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorHee Jun Cho-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorYong Kyung Choe-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.alternativeName김태우-
dc.contributor.alternativeName이선진-
dc.contributor.alternativeName박영준-
dc.contributor.alternativeName박상윤-
dc.contributor.alternativeName오병무-
dc.contributor.alternativeName박연선-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName이영하-
dc.contributor.alternativeName조희준-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName최용경-
dc.contributor.alternativeName이희구-
dc.identifier.bibliographicCitationTumor Biology, vol. 39, no. 10, pp. 1-13-
dc.identifier.doi10.1177/1010428317733985-
dc.subject.keywordcell death-
dc.subject.keyworddocetaxel-
dc.subject.keywordmitochondrial depolarization-
dc.subject.keywordmitophagy-
dc.subject.keywordOpa-interacting protein 5-
dc.subject.localcell death-
dc.subject.localCell death-
dc.subject.localdocetaxel-
dc.subject.localDocetaxel-
dc.subject.localMitochondrial depolarization-
dc.subject.localmitochondrial depolarization-
dc.subject.localmitophagy-
dc.subject.localMitophagy-
dc.subject.localOpa-interacting protein 5-
dc.description.journalClassN-
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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