On-chip fluorescence switching system for constructing a rewritable random access data storage device

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Title
On-chip fluorescence switching system for constructing a rewritable random access data storage device
Author(s)
H H Nguyen; Jeho Park; Seungwoo HwangOh Seok KwonChang-Soo LeeYong Beom ShinTai Hwan HaMoonil Kim
Bibliographic Citation
Scientific Reports, vol. 8, pp. 337-337
Publication Year
2018
Abstract
We report the development of on-chip fluorescence switching system based on DNA strand displacement and DNA hybridization for the construction of a rewritable and randomly accessible data storage device. In this study, the feasibility and potential effectiveness of our proposed system was evaluated with a series of wet experiments involving 40 bits (5 bytes) of data encoding a 5-charactered text (KRIBB). Also, a flexible data rewriting function was achieved by converting fluorescence signals between "ON" and "OFF" through DNA strand displacement and hybridization events. In addition, the proposed system was successfully validated on a microfluidic chip which could further facilitate the encoding and decoding process of data. To the best of our knowledge, this is the first report on the use of DNA hybridization and DNA strand displacement in the field of data storage devices. Taken together, our results demonstrated that DNA-based fluorescence switching could be applicable to construct a rewritable and randomly accessible data storage device through controllable DNA manipulations
ISSN
2045-2322
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/s41598-017-16535-7
Type
Article
Appears in Collections:
Korea Bioinformation Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Division of Biomaterials Research > Bionanotechnology Research Center > 1. Journal Articles
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