VBP1 represses cancer metastasis by enhancing HIF-1α degradation induced by pVHL

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Title
VBP1 represses cancer metastasis by enhancing HIF-1α degradation induced by pVHL
Author(s)
J A Kim; D K Choi; J S Min; I Kang; J C Kim; Semi Kim; J K Ahn
Bibliographic Citation
FEBS Journal, vol. 285, no. 1, pp. 115-126
Publication Year
2018
Abstract
von Hippel-Lindau-binding protein 1 (VBP1) physically interacts with pVHL, an E3-ubiquitin ligase, which degrades HIF-1α in an oxygen-dependent manner. HIF-1 is a key regulator of adaptive responses to a lack of oxygen that controls glucose metabolism, angiogenesis, proliferation, invasion, and metastasis. However, the role of VBP1 in pVHL-mediated degradation of HIF-1α is not yet known. In this study, we show that VBP1 enhances the stability of pVHL and facilitates pVHL-mediated ubiquitination of HIF-1α. Furthermore, VBP1 suppresses HIF-1α-induced epithelial-mesenchymal transition in vitro and tumor metastasis in vivo. These findings suggest that VBP1 is a bona fide tumor suppressor protein associated with HIF-1α regulation.
Keyword
EMTpVHLHIF-1αVBP1metastasis
ISSN
1742-464X
Publisher
Wiley
DOI
http://dx.doi.org/10.1111/febs.14322
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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