Isolation and structure determination of a new lumichrome glycoside isolated from a soil Streptomyces sp. KCB16C001 = 토양방선균으로부터 분리한 신규 루미크롬 화합물

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Title
Isolation and structure determination of a new lumichrome glycoside isolated from a soil Streptomyces sp. KCB16C001 = 토양방선균으로부터 분리한 신규 루미크롬 화합물
Author(s)
Sangkeun Son; Eun Kim; Jong Won Kim; Sung-Kyun Ko; Byeongsan Lee; Jung-Sook LeeYoung-Soo HongJae-Hyuk JangJong Seog Ahn
Bibliographic Citation
Natural Product Communications, vol. 13, no. 2, pp. 153-156
Publication Year
2018
Abstract
Microbial studies of soil samples collected at Ochang, Korea led to the isolation of the actinobacterium Streptomyces sp. KCB16C001. Subsequent LC/MS analysis of the culture extract for dereplication purposes enabled the identification of a new metabolite ochangoside (1), whose chemical structure was determined to be 1-(α-L-rhamnosyl)-lumichrome by scale-up purification and structure elucidation procedures based mainly on NMR and MS spectroscopic data. Determination of the stereochemistry of the sugar moiety was achieved by LC/MS analysis of the sugar derivatized with L-cysteine methyl ester and o-tolyl isothiocyanate. Our results represent arare example of natural lumichrome glycoside with a sugar unit attached at N-1.
Keyword
Lumichrome.Streptomyces sp.Structure elucidation
ISSN
1934-578X
Publisher
Sage
DOI
http://dx.doi.org/10.1177/1934578x1801300211
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
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