Enhancement of L-threonine production by controlling sequential carbon-nitrogen ratios during fermentation

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Title
Enhancement of L-threonine production by controlling sequential carbon-nitrogen ratios during fermentation
Author(s)
Hyeok Won Lee; Hee Suk Lee; Chun Suk Kim; Jin Gyeom LeeWon-Kyo KimEun Gyo LeeHong-Weon Lee
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 28, no. 2, pp. 293-297
Publication Year
2018
Abstract
Controlling the residual glucose concentration is important for improving productivity in L-threonine fermentation. In this study, we developed a procedure to automatically control the feeding quantity of glucose solution as a function of ammonia-water consumption rate. The feeding ratio (RC/N) of glucose and ammonia water was predetermined via a stoichiometric approach, on the basis of glucose-ammonia water consumption rates. In a 5-L fermenter, 102 g/l L-threonine was obtained using our glucose-ammonia water combined feeding strategy, which was then successfully applied in a 500-L fermenter (89 g/l). Therefore, we conclude that an automatic combination feeding strategy is suitable for improving L-threonine production
Keyword
L-threoninefeeding ratio (Rc/n)feeding strategyresidual glucose concentrationscale-up
ISSN
1017-7825
Publisher
South Korea
DOI
http://dx.doi.org/10.4014/jmb.1708.08072
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > BioProcess Engineering Center > 1. Journal Articles
Division of Bio Technology Innovation > 1. Journal Articles
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