Oleanolic acid acetate attenuates polyhexamethylene guanidine phosphate-induced pulmonary inflammation and fibrosis in mice

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dc.contributor.authorM S Kim-
dc.contributor.authorJ Y Han-
dc.contributor.authorS H Kim-
dc.contributor.authorD Jeon-
dc.contributor.authorH Y Kim-
dc.contributor.authorSeung Woong Lee-
dc.contributor.authorMun Chual Rho-
dc.contributor.authorK Lee-
dc.date.accessioned2018-04-19T05:19:07Z-
dc.date.available2018-04-19T05:19:07Z-
dc.date.issued2018-
dc.identifier.issn15699048-
dc.identifier.uri10.1016/j.resp.2018.03.001ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/17764-
dc.description.abstractOleanolic acid acetate (OAA), triterpenoid compound isolated from Vigna angularis (azuki bean), has been revealed anti-inflammatory in several studies. We investigated the effects of OAA against polyhexamethylene guanidine phosphate (PHMG-P)-induced pulmonary inflammation and fibrosis in mice. OAA treatment effectively alleviated PHMG-P-induced lung injury, including the number of total and differential cell in BAL fluid, histopathological lesions and hydroxyproline content in a dose dependent manner. Moreover, OAA treatment significantly decreased the elevations of IL-1β, IL-6, TNF-α, TGF-β1, and fibronectin, and the activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in the lungs of PHMG-P-treated mice. Cytokines are known to be key modulators in the inflammatory responses that drive progression of fibrosis in injured tissues. The activation of NLRP3 inflammasome has been reported to be involved in induction of inflammatory cytokines. These results indicate that OAA may mitigate the inflammatory response and development of pulmonary fibrosis in the lungs of mice treated with PHMG-P-
dc.publisherElsevier-
dc.titleOleanolic acid acetate attenuates polyhexamethylene guanidine phosphate-induced pulmonary inflammation and fibrosis in mice-
dc.title.alternativeOleanolic acid acetate attenuates polyhexamethylene guanidine phosphate-induced pulmonary inflammation and fibrosis in mice-
dc.typeArticle-
dc.citation.titleRespiratory Physiology & Neurobiology-
dc.citation.number0-
dc.citation.endPage9-
dc.citation.startPage1-
dc.citation.volume252-
dc.contributor.affiliatedAuthorSeung Woong Lee-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.alternativeName김민석-
dc.contributor.alternativeName한진영-
dc.contributor.alternativeName김성환-
dc.contributor.alternativeName전도인-
dc.contributor.alternativeName김현영-
dc.contributor.alternativeName이승웅-
dc.contributor.alternativeName노문철-
dc.contributor.alternativeName이규홍-
dc.identifier.bibliographicCitationRespiratory Physiology & Neurobiology, vol. 252, pp. 1-9-
dc.identifier.doi10.1016/j.resp.2018.03.001-
dc.subject.keywordCytokine-
dc.subject.keywordInflammasome-
dc.subject.keywordLung injury-
dc.subject.keywordOleanolic acid acetate-
dc.subject.keywordPolyhexamethylene guanidine phosphate-
dc.subject.keywordVigna angularis-
dc.subject.localCytokine-
dc.subject.localCytokines-
dc.subject.localcytokine-
dc.subject.localInflammasome-
dc.subject.localinflammasome-
dc.subject.localLung injury-
dc.subject.localOleanolic acid acetate-
dc.subject.localoleanolic acid acetate-
dc.subject.localPolyhexamethylene guanidine phosphate-
dc.subject.localvigna angularis-
dc.subject.localVigna angularis-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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