Eucalyptus globulus inhibits inflammasome-activated pro-inflammatory responses and ameliorate monosodium urate-induced peritonitis in murine experimental model

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dc.contributor.authorY E Ji-
dc.contributor.authorX Sun-
dc.contributor.authorM K Kim-
dc.contributor.authorW Y Li-
dc.contributor.authorSang Woo Lee-
dc.contributor.authorS Koppula-
dc.contributor.authorS H Yu-
dc.contributor.authorH B Kim-
dc.contributor.authorT B Kang-
dc.contributor.authorK H Lee-
dc.date.accessioned2018-04-19T05:19:07Z-
dc.date.available2018-04-19T05:19:07Z-
dc.date.issued2018-
dc.identifier.issn0192-415X-
dc.identifier.uri10.1142/S0192415X18500210ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/17765-
dc.description.abstractEucalyptus globulus Labill. (E. globulus, Myrtaceae) is used in Europe as a traditional folk remedy for inflammation-related disorders such as arthritis, diabetes, asthma, and gout. We investigated this study to evaluate the protective effects of E. globulus extract (EG) on inflammatory responses, and provide scientific and mechanistic evidence in in vitro and in vivo experimental models. LPS-stimulated murine bone marrow-derived macrophages (BMDMs) were used to study the regulatory effect of EG on inflammasome activation in vitro. Monosodium urate (MSU)-induced peritonitis was used to study the effect of EG in an in vivo murine model. EG suppressed IL-1β secretion via the regulation of apoptosis-associated speck-like proteins containing a CARD (ASC) oligomerization and caspase-1 maturation, leading to the inhibition of inflammasome activation. In the in vivo study, EG suppressed the MSU-induced peritonitis by attenuating interleukin (IL)-1β, providing scientific support for its traditional use in the treatment of inflammation-related disorders.-
dc.publisherWorld Scientific Publ Co Pte Ltd-
dc.titleEucalyptus globulus inhibits inflammasome-activated pro-inflammatory responses and ameliorate monosodium urate-induced peritonitis in murine experimental model-
dc.title.alternativeEucalyptus globulus inhibits inflammasome-activated pro-inflammatory responses and ameliorate monosodium urate-induced peritonitis in murine experimental model-
dc.typeArticle-
dc.citation.titleAmerican Journal of Chinese Medicine-
dc.citation.number2-
dc.citation.endPage433-
dc.citation.startPage423-
dc.citation.volume46-
dc.contributor.affiliatedAuthorSang Woo Lee-
dc.contributor.alternativeName지영은-
dc.contributor.alternativeNameSun-
dc.contributor.alternativeName김명기-
dc.contributor.alternativeNameLi-
dc.contributor.alternativeName이상우-
dc.contributor.alternativeNameKoppula-
dc.contributor.alternativeName유상현-
dc.contributor.alternativeName김한비-
dc.contributor.alternativeName강태봉-
dc.contributor.alternativeName이광호-
dc.identifier.bibliographicCitationAmerican Journal of Chinese Medicine, vol. 46, no. 2, pp. 423-433-
dc.identifier.doi10.1142/S0192415X18500210-
dc.subject.keywordASC-
dc.subject.keywordEucalyptus globulus Labill-
dc.subject.keywordInflammasome-
dc.subject.keywordPeritonitis-
dc.subject.localASC-
dc.subject.localEucalyptus globulus Labill-
dc.subject.localinflammasome-
dc.subject.localInflammasome-
dc.subject.localperitonitis-
dc.subject.localPeritonitis-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > International Biological Material Research Center > 1. Journal Articles
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