Genetic incorporation of l-dihydroxyphenylalanine (DOPA) biosynthesized by a tyrosine phenol-lyase
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- Title
- Genetic incorporation of l-dihydroxyphenylalanine (DOPA) biosynthesized by a tyrosine phenol-lyase
- Author(s)
- S Kim; Bong Hyun Sung; S C Kim; H S Lee
- Bibliographic Citation
- Chemical Communications, vol. 54, no. 24, pp. 3002-3005
- Publication Year
- 2018
- Abstract
- l-Dihydroxyphenylalanine (DOPA) was biosynthesized by a tyrosine-phenol lyase from catechol, pyruvate, and ammonia in Escherichia coli, and the biosynthesized amino acid was directly incorporated into proteins. Three biochemical experiments with mutant proteins containing DOPA confirmed the genetic incorporation of biosynthesized DOPA, and revealed its potential for various biochemical applications
- ISSN
- 1359-7345
- Publisher
- Royal Soc Chem
- Full Text Link
- http://dx.doi.org/10.1039/c8cc00281a
- Type
- Article
- Appears in Collections:
- Synthetic Biology and Bioengineering Research Institute > 1. Journal Articles
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