Genetic incorporation of l-dihydroxyphenylalanine (DOPA) biosynthesized by a tyrosine phenol-lyase

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Title
Genetic incorporation of l-dihydroxyphenylalanine (DOPA) biosynthesized by a tyrosine phenol-lyase
Author(s)
S Kim; Bong Hyun Sung; S C Kim; H S Lee
Bibliographic Citation
Chemical Communications, vol. 54, no. 24, pp. 3002-3005
Publication Year
2018
Abstract
l-Dihydroxyphenylalanine (DOPA) was biosynthesized by a tyrosine-phenol lyase from catechol, pyruvate, and ammonia in Escherichia coli, and the biosynthesized amino acid was directly incorporated into proteins. Three biochemical experiments with mutant proteins containing DOPA confirmed the genetic incorporation of biosynthesized DOPA, and revealed its potential for various biochemical applications
ISSN
1359-7345
Publisher
Royal Soc Chem
DOI
http://dx.doi.org/10.1039/c8cc00281a
Type
Article
Appears in Collections:
Synthetic Biology and Bioengineering Research Institute > Synthetic Biology Research Center > 1. Journal Articles
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