In vitro and in vivo safety studies of cinnamon extract (Cinnamomum cassia) on general and genetic toxicology

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Title
In vitro and in vivo safety studies of cinnamon extract (Cinnamomum cassia) on general and genetic toxicology
Author(s)
J W Yun; J R You; Y S Kim; S H Kim; E Y Cho; J H Yoon; E Kwon; J J Jang; J S Park; Hyoung-Chin Kim; J H Che; B C Kang
Bibliographic Citation
Regulatory Toxicology and Pharmacology, vol. 95, pp. 115-123
Publication Year
2018
Abstract
Cinnamomum cassia has been widely used as a natural product to treat diseases in Asia due to its diverse pharmacological functions including anti-inflammatory, anti-oxidant, anti-microbial, anti-diabetic, and anti-tumor effects. Despite its ethnomedicinal benefits, little information regarding its toxicity is currently available. The aim of this study was to evaluate its potential long-term toxicity and genotoxicity in compliance with test guidelines of the Organization for Economic Cooperation and Development. A 13-week repeat-dose oral toxicity study revealed that body weights of rats were normal after receiving cinnamon extract at up to 2000 mg/kg. High-dose intake of cinnamon extract (2000 mg/kg) showed potential nephrotoxicity and hepatotoxicity to both males and females as evidenced by obvious increases of kidney/liver weight along with a small but statistically elevation of total cholesterol level. Overall findings from genetic toxicity testing battery including Ames test, in vitro mammalian cell micronucleus assay, and in vivo bone marrow micronucleus assay indicated that cinnamon extract was not mutagenic or clastogenic. In conclusion, cinnamon extract may possess potential nephrotoxicity and hepatotoxicity at dose higher than its recommended daily safe dose. Further study is needed to clarify the mechanism involved in its induction of liver and kidney injury
Keyword
Cinnamomum cassiaCinnamonGenotoxicitySubchronicToxicity
ISSN
0273-2300
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.yrtph.2018.02.017
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > 1. Journal Articles
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