Perfluorooctane sulfonate exacerbates mast cell-mediated allergic inflammation by the release of histamine

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Title
Perfluorooctane sulfonate exacerbates mast cell-mediated allergic inflammation by the release of histamine
Author(s)
J K Lee; Soyoung Lee; Y A Choi; M Jin; Y Y Kim; B C Kang; M J Kim; H Dhakal; Sang-Rae Lee; Sun-Uk Kim; D Khang; S H Kim
Bibliographic Citation
Molecular & Cellular Toxicology, vol. 14, no. 2, pp. 173-181
Publication Year
2018
Abstract
Backgrounds: Mast cells play a major role in allergic inflammation by the release of histamine, an important mediator of type I hypersensitivity. Cencerns regarding potential harmful effects of perfluorooctane sulfonate (PFOS) have been raised. Previous studies reported that PFOS causes various adverse effects such as immunotoxicity and neurotoxicity. This report studied whether PFOS affects mast cells-mediated allergic inflammation. Methods: Ovalbumin-induced active systemic anaphylaxis model was used to assess for the type I hypersensitivity. After sensitization, mice were orally administered with PFOS and then allergic symptoms such as hypothermia and increase of serum allergic mediator were measured. In additional, this study investigated whether PFOS deteriorate allergic inflammation in immunoglobulin E-stimulated mast cells. Results: PFOS aggravated the allergic symptoms such as hypothermia, and increase of serum histamine, tumor necrosis factor-α and immunoglobulin (Ig) E/ G1. PFOS increased the release of histamine and β-hexosaminidase through the up-regulation of intracellular calcium in IgE-stimulated mast cells. PFOS also enhanced the gene expression of pro-inflammatory cytokines by activating nuclear factor-κB. Conclusion: This study demonstrated that PFOS more intensifies the mast cell-mediated allergic inflammation
Keyword
Allergic inflammationHistamineMast cellsNuclear factor-κBPerfluorooctane sulfonate
ISSN
I000-0184
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.1007/s13273-018-0019-z
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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