A new flavonoid from Stellera chamaejasme L., stechamone, alleviated 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in a murine model

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dc.contributor.authorB G Jo-
dc.contributor.authorN J Park-
dc.contributor.authorJ Jegal-
dc.contributor.authorSangho Choi-
dc.contributor.authorSang Woo Lee-
dc.contributor.authorH Jin-
dc.contributor.authorS N Kim-
dc.contributor.authorM H Yang-
dc.date.accessioned2018-07-19T16:30:09Z-
dc.date.available2018-07-19T16:30:09Z-
dc.date.issued2018-
dc.identifier.issn1567-5769-
dc.identifier.uri10.1016/j.intimp.2018.04.008ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/17829-
dc.description.abstractStellera chamaejasme L. (family Thymelaeaceae), also known as ‘Langdu’ has been traditionally used to treat of skin-related diseases, such as, psoriasis and skin ulcers. The aim of this study was to identify the biologically active component of S. chamaejasme and evaluate its preventive effects on IL-4 and mast cell degranulation in RBL-2H3 cells and on the development of atopic dermatitis (AD) in 2,4-dinitrochlorobenzene (DNCB)-treated SKH-1 hairless mice. A novel flavonoid, genkwanin 5-O-xylosyl(1 → 2)glucoside (named stechamone), and three known compounds (umbelliferone, luteolin, and luteolin-7-O-glucoside) were isolated from the aerial parts of S. chamaejasme using chromatographic methods. Of these four compounds, stechamone most potently inhibited IL-4 production and mast cell degranulation in RBL-2H3 cells. Topical application of 0.5% stechamone improved atopic skin symptoms, including, erythema (redness), pruritus (itching), exudation (weeping), excoriation (peeling), and lichenification (skin thickening) in DNCB-treated AD mice by accelerating skin barrier recovery function and suppressing inflammatory cell infiltration. In addition, stechamone attenuated DNCB-induced increases in IL-4 (an inflammatory TH2 cytokine) expression and in serum IgE levels in our murine model of AD. DNCB induced AD-like skin lesions, but treatment with stechamone exhibited strong anti-atopic activity by regulating skin barrier function and reducing inflammatory responses. The results obtained suggest stechamone is a potential anti-atopic agent and treatment for skin inflammatory diseases-
dc.publisherElsevier-
dc.titleA new flavonoid from Stellera chamaejasme L., stechamone, alleviated 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in a murine model-
dc.title.alternativeA new flavonoid from Stellera chamaejasme L., stechamone, alleviated 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in a murine model-
dc.typeArticle-
dc.citation.titleInternational Immunopharmacology-
dc.citation.number0-
dc.citation.endPage119-
dc.citation.startPage113-
dc.citation.volume59-
dc.contributor.affiliatedAuthorSangho Choi-
dc.contributor.affiliatedAuthorSang Woo Lee-
dc.contributor.alternativeName조범근-
dc.contributor.alternativeName박노준-
dc.contributor.alternativeName제갈종환-
dc.contributor.alternativeName최상호-
dc.contributor.alternativeName이상우-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName김수남-
dc.contributor.alternativeName양민혜-
dc.identifier.bibliographicCitationInternational Immunopharmacology, vol. 59, pp. 113-119-
dc.identifier.doi10.1016/j.intimp.2018.04.008-
dc.subject.keyword2,4-Dinitrochlorobenzene-
dc.subject.keywordAtopic dermatitis-
dc.subject.keywordInterleukin 4-
dc.subject.keywordSkin barrier function-
dc.subject.keywordStechamone-
dc.subject.keywordStellera chamaejasme L.-
dc.subject.local2,4-Dinitrochlorobenzene-
dc.subject.local2,4-dinitrochlorobenzene-
dc.subject.localAtopic Dermatitis-
dc.subject.localAtopic dermatitis-
dc.subject.localatopic dermatitis-
dc.subject.localatopic dermatitis (AD)-
dc.subject.localAtopic dermatitis (AD)-
dc.subject.localInterleukin 4-
dc.subject.localInterleukin-4-
dc.subject.localinterleukin 4-
dc.subject.localInterleukin 4 (IL-4)-
dc.subject.localSkin barrier function-
dc.subject.localskin barrier function-
dc.subject.localStechamone-
dc.subject.localStellera chamaejasme-
dc.subject.localStellera chamaejasme L.-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > International Biological Material Research Center > 1. Journal Articles
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