Metabolic engineering of Corynebacterium glutamicum for fermentative production of chemicals in biorefinery

Cited 43 time in scopus
Metadata Downloads
Title
Metabolic engineering of Corynebacterium glutamicum for fermentative production of chemicals in biorefinery
Author(s)
K A Baritugo; H T Kim; Y David; J I Choi; S H Hong; K J Jeong; Jong Hyun Choi; J C Joo; S J Park
Bibliographic Citation
Applied Microbiology and Biotechnology, vol. 102, no. 9, pp. 3915-3937
Publication Year
2018
Abstract
Bio-based production of industrially important chemicals provides an eco-friendly alternative to current petrochemical-based processes. Because of the limited supply of fossil fuel reserves, various technologies utilizing microbial host strains for the sustainable production of platform chemicals from renewable biomass have been developed. Corynebacterium glutamicum is a non-pathogenic industrial microbial species traditionally used for l-glutamate and l-lysine production. It is a promising species for industrial production of bio-based chemicals because of its flexible metabolism that allows the utilization of a broad spectrum of carbon sources and the production of various amino acids. Classical breeding, systems, synthetic biology, and metabolic engineering approaches have been used to improve its applications, ranging from traditional amino-acid production to modern biorefinery systems for production of value-added platform chemicals. This review describes recent advances in the development of genetic engineering tools and techniques for the establishment and optimization of metabolic pathways for bio-based production of major C2?C6 platform chemicals using recombinant C. glutamicum
Keyword
Bio-based chemicalsCorynebacterium glutamicumMetabolic engineeringMicrobial cell factoryPlasmid vectorsPromoters
ISSN
0175-7598
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s00253-018-8896-6
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.