Virological and pathological characterization of an avian H1N1 influenza A virus

Cited 6 time in scopus
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Title
Virological and pathological characterization of an avian H1N1 influenza A virus
Author(s)
Bon Sang Koo; Hye Kwon Kim; D Song; W Na; M S Song; J J Kwon; S S Wong; Ji Yeong Noh; Min Ju Ahn; Doo-Jin Kim; R J Webby; Sun Woo Yoon; Dae Gwin Jeong
Bibliographic Citation
Archives of Virology, vol. 163, no. 5, pp. 1153-1162
Publication Year
2018
Abstract
Gene segments from avian H1N1 influenza A viruses have reassorted with other influenza viruses to generate pandemic strains over the past century. Nevertheless, little effort has been invested in understanding the characteristics of avian H1N1 influenza viruses. Here, we present the genome sequence and a molecular and virological characterization of an avian influenza A virus, A/wild bird/Korea/SK14/2014 (A/SK14, H1N1), isolated from migratory birds in South Korea during the winter season of 2014-2015. Full-genome sequencing and phylogenetic analysis revealed that the virus belongs to the Eurasian avian lineage. Although it retained avian-receptor binding preference, A/SK14 virus also exhibited detectable human-like receptor binding and was able to replicate in differentiated primary normal human bronchial epithelial cells. In animal models, A/SK14 virus was moderately pathogenic in mice, and virus was detected in nasal washes from inoculated guinea pigs, but not in direct-contact guinea pigs. Although A/SK14 showed moderate pathogenicity and no evidence of transmission in a mammalian model, our results suggest that the dual receptor specificity of A/SK14-like virus might allow for a more rapid adaptation to mammals, emphasizing the importance of further continuous surveillance and risk-assessment activities
ISSN
0304-8608
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s00705-018-3730-0
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Division of Research on National Challenges > Bionanotechnology Research Center > 1. Journal Articles
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