DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gil Su Kim | - |
dc.contributor.author | W Ko | - |
dc.contributor.author | Jong Won Kim | - |
dc.contributor.author | M H Jeong | - |
dc.contributor.author | Sung-Kyun Ko | - |
dc.contributor.author | J S Hur | - |
dc.contributor.author | H Oh | - |
dc.contributor.author | Jae-Hyuk Jang | - |
dc.contributor.author | Jong Seog Ahn | - |
dc.date.accessioned | 2018-07-19T16:30:19Z | - |
dc.date.available | 2018-07-19T16:30:19Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | 10.1021/acs.jnatprod.7b01022 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/17860 | - |
dc.description.abstract | Two new α-pyrones, dothideopyrones E (1) and F (2), were isolated from a culture of the endolichenic fungus Dothideomycetes sp. EL003334. Their structures were elucidated by spectroscopic data analysis. Their absolute configurations were established by the modified Mosher's method. Compound 2 inhibited nitric oxide (NO) production with IC50 values of 15.0 ± 2.8 μM in lipopolysaccharide (LPS)-induced BV2 cells. Compound 2 diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, 2 decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6. | - |
dc.publisher | Amer Chem Soc | - |
dc.title | Bioactive α-pyrone derivatives from the endolichenic fungus Dothideomycetes sp. EL003334 = 지의류 내생 곰팡이로부터 분리한 신규물질 | - |
dc.title.alternative | Bioactive α-pyrone derivatives from the endolichenic fungus Dothideomycetes sp. EL003334 | - |
dc.type | Article | - |
dc.citation.title | Journal of Natural Products | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 1088 | - |
dc.citation.startPage | 1084 | - |
dc.citation.volume | 81 | - |
dc.contributor.affiliatedAuthor | Gil Su Kim | - |
dc.contributor.affiliatedAuthor | Jong Won Kim | - |
dc.contributor.affiliatedAuthor | Sung-Kyun Ko | - |
dc.contributor.affiliatedAuthor | Jae-Hyuk Jang | - |
dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
dc.contributor.alternativeName | 김길수 | - |
dc.contributor.alternativeName | 고원민 | - |
dc.contributor.alternativeName | 김종원 | - |
dc.contributor.alternativeName | 정민혜 | - |
dc.contributor.alternativeName | 고성균 | - |
dc.contributor.alternativeName | 허재선 | - |
dc.contributor.alternativeName | 오현철 | - |
dc.contributor.alternativeName | 장재혁 | - |
dc.contributor.alternativeName | 안종석 | - |
dc.identifier.bibliographicCitation | Journal of Natural Products, vol. 81, no. 4, pp. 1084-1088 | - |
dc.identifier.doi | 10.1021/acs.jnatprod.7b01022 | - |
dc.description.journalClass | Y | - |
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