Cytotoxic drimane sesquiterpenoids isolated from Perenniporia maackiae

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Title
Cytotoxic drimane sesquiterpenoids isolated from Perenniporia maackiae
Author(s)
J Kwon; H Lee; Y H Seo; J Yun; J Lee; H C Kwon; Y Guo; Jong Soon Kang; J J Kim; D Lee
Bibliographic Citation
Journal of Natural Products, vol. 81, no. 6, pp. 1444-1450
Publication Year
2018
Abstract
A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/acs.jnatprod.8b00175
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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