Genkwalathins A and B, new lathyrane-type diterpenes from Daphne genkwa

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dc.contributor.authorN V Minh-
dc.contributor.authorBaek Soo Han-
dc.contributor.authorHa Young Choi-
dc.contributor.authorJeong Su Byun-
dc.contributor.authorJi Su Park-
dc.contributor.authorWon Gon Kim-
dc.date.accessioned2018-07-19T16:30:46Z-
dc.date.available2018-07-19T16:30:46Z-
dc.date.issued2018-
dc.identifier.issn10292349-
dc.identifier.uri10.1080/14786419.2017.1402322ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/17955-
dc.description.abstractScreening for new natural anti-neuroinflammatory compounds was performed with the traditional folk medicine Genkwa Flos, which potently inhibited nitric oxide (NO) production by LPS-activated microglial BV-2 cells. Two new lathyrane-type diterpenes, genkwalathins A (1) and B (2), and 14 known daphnane-type diterpenes (3?16) were isolated. The lathyrane-type diterpenes were isolated for the first time from the Thymelaeaceae family in this study. Compounds 1 and 2 moderately inhibited LPS-induced NO production in BV-2 cells without affecting cell viability, while six daphnane-type diterpenes (3, 4, 6, 7, 9 and 10) potently reduced NO production with IC50 values less than 1 μM, although they did display weak cytotoxicity. A structure?activity relationship study on the daphnane-type diterpenes indicated that the stereochemistry at C-19, the benzoate group at C-20, and the epoxide moiety could be important for their anti-neuroinflammatory effects.-
dc.publisherT&F (Taylor & Francis)-
dc.titleGenkwalathins A and B, new lathyrane-type diterpenes from Daphne genkwa-
dc.title.alternativeGenkwalathins A and B, new lathyrane-type diterpenes from Daphne genkwa-
dc.typeArticle-
dc.citation.titleNatural Product Research-
dc.citation.number15-
dc.citation.endPage1790-
dc.citation.startPage1782-
dc.citation.volume32-
dc.contributor.affiliatedAuthorBaek Soo Han-
dc.contributor.affiliatedAuthorJeong Su Byun-
dc.contributor.affiliatedAuthorWon Gon Kim-
dc.contributor.alternativeNameMinh-
dc.contributor.alternativeName한백수-
dc.contributor.alternativeName최하영-
dc.contributor.alternativeName변정수-
dc.contributor.alternativeName박지수-
dc.contributor.alternativeName김원곤-
dc.identifier.bibliographicCitationNatural Product Research, vol. 32, no. 15, pp. 1782-1790-
dc.identifier.doi10.1080/14786419.2017.1402322-
dc.subject.keywordanti-neuroinflammatory-
dc.subject.keyworddaphnane-type diterpene-
dc.subject.keywordDaphne genkwa-
dc.subject.keywordGenkwa Flos-
dc.subject.keywordlathyrane-type diterpene-
dc.subject.localanti-neuroinflammatory-
dc.subject.localAnti-neuroinflammatory-
dc.subject.localdaphnane-type diterpene-
dc.subject.localDaphnane-type diterpene-
dc.subject.localDaphne genkwa-
dc.subject.localGenkwa Flos-
dc.subject.locallathyrane-type diterpene-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Biodefense Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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