DC Field | Value | Language |
---|---|---|
dc.contributor.author | N V Minh | - |
dc.contributor.author | Baek Soo Han | - |
dc.contributor.author | Ha Young Choi | - |
dc.contributor.author | Jeong Su Byun | - |
dc.contributor.author | Ji Su Park | - |
dc.contributor.author | Won Gon Kim | - |
dc.date.accessioned | 2018-07-19T16:30:46Z | - |
dc.date.available | 2018-07-19T16:30:46Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1029-2349 | - |
dc.identifier.uri | 10.1080/14786419.2017.1402322 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/17955 | - |
dc.description.abstract | Screening for new natural anti-neuroinflammatory compounds was performed with the traditional folk medicine Genkwa Flos, which potently inhibited nitric oxide (NO) production by LPS-activated microglial BV-2 cells. Two new lathyrane-type diterpenes, genkwalathins A (1) and B (2), and 14 known daphnane-type diterpenes (3-16) were isolated. The lathyrane-type diterpenes were isolated for the first time from the Thymelaeaceae family in this study. Compounds 1 and 2 moderately inhibited LPS-induced NO production in BV-2 cells without affecting cell viability, while six daphnane-type diterpenes (3, 4, 6, 7, 9 and 10) potently reduced NO production with IC50 values less than 1 μM, although they did display weak cytotoxicity. A structure-activity relationship study on the daphnane-type diterpenes indicated that the stereochemistry at C-19, the benzoate group at C-20, and the epoxide moiety could be important for their anti-neuroinflammatory effects. | - |
dc.publisher | T&F (Taylor & Francis) | - |
dc.title | Genkwalathins A and B, new lathyrane-type diterpenes from Daphne genkwa | - |
dc.title.alternative | Genkwalathins A and B, new lathyrane-type diterpenes from Daphne genkwa | - |
dc.type | Article | - |
dc.citation.title | Natural Product Research | - |
dc.citation.number | 15 | - |
dc.citation.endPage | 1790 | - |
dc.citation.startPage | 1782 | - |
dc.citation.volume | 32 | - |
dc.contributor.affiliatedAuthor | Baek Soo Han | - |
dc.contributor.affiliatedAuthor | Ha Young Choi | - |
dc.contributor.affiliatedAuthor | Jeong Su Byun | - |
dc.contributor.affiliatedAuthor | Ji Su Park | - |
dc.contributor.affiliatedAuthor | Won Gon Kim | - |
dc.contributor.alternativeName | Minh | - |
dc.contributor.alternativeName | 한백수 | - |
dc.contributor.alternativeName | 최하영 | - |
dc.contributor.alternativeName | 변정수 | - |
dc.contributor.alternativeName | 박지수 | - |
dc.contributor.alternativeName | 김원곤 | - |
dc.identifier.bibliographicCitation | Natural Product Research, vol. 32, no. 15, pp. 1782-1790 | - |
dc.identifier.doi | 10.1080/14786419.2017.1402322 | - |
dc.subject.keyword | anti-neuroinflammatory | - |
dc.subject.keyword | daphnane-type diterpene | - |
dc.subject.keyword | Daphne genkwa | - |
dc.subject.keyword | Genkwa Flos | - |
dc.subject.keyword | lathyrane-type diterpene | - |
dc.subject.local | Anti-neuroinflammatory | - |
dc.subject.local | anti-neuroinflammatory | - |
dc.subject.local | Daphnane-type diterpene | - |
dc.subject.local | daphnane-type diterpene | - |
dc.subject.local | Daphne genkwa | - |
dc.subject.local | Genkwa Flos | - |
dc.subject.local | lathyrane-type diterpene | - |
dc.description.journalClass | Y | - |
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