Antiadipogenic effects of loganic acid in 3T3-L1 preadipocytes and ovariectomized mice

Cited 16 time in scopus
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Title
Antiadipogenic effects of loganic acid in 3T3-L1 preadipocytes and ovariectomized mice
Author(s)
E Park; J Kim; S Yeo; G Kim; E H Ko; Sang Woo Lee; W Y Li; C W Choi; S Y Jeong
Bibliographic Citation
Molecules, vol. 23, no. 7, pp. 1663-1663
Publication Year
2018
Abstract
Obesity is caused by an excess storage of body fat, resulting from a chronic imbalance between energy intake and expenditure. Gentiana lutea L. (GL) root has been reported to reduce lipid accumulation in the aortic wall of diabetic rats. Here, we performed fractionation and isolation of the bioactive constituent(s) that may be responsible for the antiadipogenic effects of the GL root extract. A single compound, loganic acid, was identified as a candidate component in the 30% ethanol extract of GL. Loganic acid treatment significantly decreased the adipocyte differentiation of 3T3-L1 preadipocytes in a dose-dependent manner. The expression of key adipogenesis-related genes such as adiponectin (Adipoq), peroxisome proliferator-activated receptor gamma (Pparg), lipoprotein lipase (Lpl), perilipin1 (Plin1), fatty acid binding protein 4 (Fabp4), glucose transporter type 4 (Slc2a4), CCAAT/enhancer-binding protein alpha (Cebpa), and tumor necrosis factor-alpha (Tnf) were significantly reduced following treatment with loganic acid. In vivo experiments in an ovariectomy-induced obesity mouse model showed that loganic acid (oral administration with 10 and 50 mg/kg/day) significantly inhibited body weight gain, total fat increase, fatty hepatocyte deposition in the liver, and adipocyte enlargement in the abdominal visceral fat tissues. These results suggest that loganic acid in the GL root extract has antiadipogenic effects in vitro and in vivo. Loganic acid may be beneficial for the prevention and treatment of obesity, particularly in menopausal obese women. ⓒ 2018 by the authors.
Keyword
3T3-L1 cellGentiana lutea L.adipogenesisloganic acidobesityovariectomized mouse
ISSN
1420-3049
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/molecules23071663
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > International Biological Material Research Center > 1. Journal Articles
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