Anti-inflammatory phomalichenones from an endolichenic fungus Phoma sp. = 지의류 내생 곰팡이로부터 분리한 항염증 물질

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Title
Anti-inflammatory phomalichenones from an endolichenic fungus Phoma sp. = 지의류 내생 곰팡이로부터 분리한 항염증 물질
Author(s)
Jong Won Kim; W Ko; E Kim; Gil Soo Kim; Gui-Ja Hwang; Sangkeun Son; M H Jeong; J S Hur; H Oh; Sung-Kyun KoJae-Hyuk JangJong Seog Ahn
Bibliographic Citation
Journal of Antibiotics, vol. 71, no. 8, pp. 753-756
Publication Year
2018
Abstract
Four new compounds, phomalichenones A-D (1-4), and seven known compounds (5-11) were isolated from the cultures of an endolichenic fungus Phoma sp. EL002650. Their structures were determined by the analysis of their spectroscopic data (NMR and MS). Compounds 1 and 6 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. In addition, compound 1 diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin(IL)-1β, and IL-6.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/s41429-018-0058-7
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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