The use of normal stem cells and cancer stem cells for potential anti-cancer therapeutic strategy

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dc.contributor.authorS W Han-
dc.contributor.authorY Y Kim-
dc.contributor.authorW J Kang-
dc.contributor.authorHyoung-Chin Kim-
dc.contributor.authorS Y Ku-
dc.contributor.authorB C Kang-
dc.contributor.authorJ W Yun-
dc.date.accessioned2018-10-24T16:30:20Z-
dc.date.available2018-10-24T16:30:20Z-
dc.date.issued2018-
dc.identifier.issn17382696-
dc.identifier.uri10.1007/s13770-018-0128-8ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18030-
dc.description.abstractBACKGROUND:: Despite recent advance in conventional cancer therapies including surgery, radiotherapy, chemotherapy, and immunotherapy to reduce tumor size, unfortunately cancer mortality and metastatic cancer incidence remain high. Along with a deeper understanding of stem cell biology, cancer stem cell (CSC) is important in targeted cancer therapy. Herein, we review representative patents using not only normal stem cells as therapeutics themselves or delivery vehicles, but also CSCs as targets for anti-cancer strategy. METHODS:: Relevant patent literatures published between 2005 and 2017 are discussed to present developmental status and experimental results on using normal stem cells and CSCs for cancer therapy and explore potential future directions in this field. RESULTS:: Stem cells have been considered as important element of regenerative therapy by promoting tissue regeneration. Particularly, there is a growing trend to use stem cells as a target drug-delivery system to reduce undesirable side effects in non-target tissues. Noteworthy, studies on CSC-specific markers for distinguishing CSCs from normal stem cells and mature cancer cells have been conducted as a selective anti-cancer therapy with few side effects. Many researchers have also reported the development of various substances with anticancer effects by targeting CSCs from cancer tissues. CONCLUSION:: There has been a continuing increase in the number of studies on therapeutic stem cells and CSC-specific markers for selective diagnosis and therapy of cancer. This review focuses on the current status in the use of normal stem cells and CSCs for targeted cancer therapy. Future direction is also proposed.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleThe use of normal stem cells and cancer stem cells for potential anti-cancer therapeutic strategy-
dc.title.alternativeThe use of normal stem cells and cancer stem cells for potential anti-cancer therapeutic strategy-
dc.typeArticle-
dc.citation.titleTissue Engineering and Regenerative Medicine-
dc.citation.number4-
dc.citation.endPage380-
dc.citation.startPage365-
dc.citation.volume15-
dc.contributor.affiliatedAuthorHyoung-Chin Kim-
dc.contributor.alternativeName한승우-
dc.contributor.alternativeName김윤영-
dc.contributor.alternativeName강우주-
dc.contributor.alternativeName김형진-
dc.contributor.alternativeName구승엽-
dc.contributor.alternativeName강병철-
dc.contributor.alternativeName윤준원-
dc.identifier.bibliographicCitationTissue Engineering and Regenerative Medicine, vol. 15, no. 4, pp. 365-380-
dc.identifier.doi10.1007/s13770-018-0128-8-
dc.subject.keywordCancer-
dc.subject.keywordCancer stem cell-
dc.subject.keywordMarker-
dc.subject.keywordStem cell-
dc.subject.keywordTargeted cancer therapy-
dc.subject.localCancer-
dc.subject.localCancers-
dc.subject.localcancer-
dc.subject.localCancer stem cell-
dc.subject.localCancer stem cells-
dc.subject.localcancer stem cell-
dc.subject.localmarker-
dc.subject.localmarkers-
dc.subject.localMarker-
dc.subject.localMarkers-
dc.subject.localmakers-
dc.subject.localStem cell-
dc.subject.localStem cells-
dc.subject.localstem cells-
dc.subject.localTargeted cancer therapy-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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