Anti-angiogenesis effects induced by octaminomycins A and B against HUVECs = 혈관 신생저해 옥타미노마이신

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Title
Anti-angiogenesis effects induced by octaminomycins A and B against HUVECs = 혈관 신생저해 옥타미노마이신
Author(s)
Jun-Pil Jang; J M Han; H J Jung; H Osada; Jae-Hyuk JangJong Seog Ahn
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 28, no. 8, pp. 1332-1338
Publication Year
2018
Abstract
In the course of studies to discover natural products with anti-angiogenic properties, two cyclic octapeptides, octaminomycins A (1) and B (2), were isolated from the cultures of Streptomyces sp. RK85-270. Octaminomycins suppressed the vascular endothelial growth factor (VEGF)-induced proliferation, adhesion, tube formation, migration, and invasion of HUVECs. Anti-angiogenic activity were futher confirmed in vivo by the chicken chorioallantoic membrane assay. We also identified that 1 and 2 inhibited the phosphorylation of VEGF receptor 2, AKT, and ERK1/2 and the expression and activities of MMP-2 and MMP-9. These results suggest that 1 and 2 may serve as potential scaffolds for the development of therapeutic agents to angiogenesis-dependent diseases.
Keyword
HUVECOctaminomycinVEGFantiangiogenesissecondary metabolites
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.4014/jmb.1806.06046
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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