Surveillance of retroelement expression and nucleic-acid immunity by histone methyltransferase SETDB1

Cited 7 time in scopus
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Title
Surveillance of retroelement expression and nucleic-acid immunity by histone methyltransferase SETDB1
Author(s)
Yong-Kook Kang
Bibliographic Citation
Bioessays, vol. 40, no. 9, pp. e1800058-e1800058
Publication Year
2018
Abstract
In human cancers, histone methyltransferase SETDB1 (SET domain, bifurcated 1) is frequently overexpressed but its significance in carcinogenesis remains elusive. A recent study shows that SETDB1 downregulation induces de-repression of retroelements and innate immunity in cancer cells. The possibility of SETDB1 functioning as a surveillant of retroelement expression is discussed in this study: the cytoplasmic presence of retroelement-derived nucleic acids (RdNAs) drives SETDB1 into the nucleus by the RNA-interference route, rendering the corresponding retroelement transcriptionally inert. These RdNAs could, therefore, be signals of genome instability sent out for SETDB1 present in the cytoplasm to maintain genome integrity.
Keyword
AGO2RNA interferenceSETDB1cancernucleic acid immunityretroelementtranscriptional gene silencing
ISSN
0265-9247
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/bies.201800058
Type
Article
Appears in Collections:
Division of Research on National Challenges > Aging Research Center > 1. Journal Articles
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