Synthetic efforts towards the stereoselective synthesis of NF00659B1
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- Title
- Synthetic efforts towards the stereoselective synthesis of NF00659B1
- Author(s)
- D Y Kwon; K Lee; H Park; Mi Jung Kim; J Hong
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry Letters, vol. 28, pp. 2746-2750
- Publication Year
- 2018
- Abstract
- NF00659B1 is a novel α-pyrone diterpenoid natural product with potent anti-colon cancer activity. A stereoselective approach to the 2,2-dimethyl oxepanol core of NF00659B1 is described enlisting a sequence of olefinic ester ring-closing metathesis, epoxidation, and Grignard addition. This strategy paves the way to a total synthesis of NF00659B1 for further biological studies.
- Keyword
- Colon cancerDimethyl oxepanolNF00659B(1)Natural productsOlefinic ester ring-closing metathesisPyrone diterpenoid
- ISSN
- 0960-894X
- Publisher
- Elsevier
- Full Text Link
- http://dx.doi.org/10.1016/j.bmcl.2018.02.038
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
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