O-carboranylalkoxy-1,3,5-triazine derivatives: synthesis, characterization, X-ray structural studies, and biological activity

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Title
O-carboranylalkoxy-1,3,5-triazine derivatives: synthesis, characterization, X-ray structural studies, and biological activity
Author(s)
G F Jin; Ban Hyun Seung; H Nakamura; J D Lee
Bibliographic Citation
Molecules, vol. 23, no. 9, pp. 2194-2194
Publication Year
2018
Abstract
Morpholine- and bis(2-methoxyethyl)amine-substituted 1,3,5-triazine derivatives containing an alkoxy-o-carborane in the 6-position of the triazine ring were successfully synthesized. The molecular structures of the methoxy- and ethoxy-o-carboranyl-1,3,5-triazines were established by X-ray crystallography. In vitro studies showed that the methylene bridged morpholine- and bis(2-methoxyethyl)amine-substituted o-carboranyl-1,3,5-triazines accumulated to high levels in B16 melanoma cells and exhibited higher cytotoxicity than p-boronophenylalanine.
Keyword
1,3,5-triazinemorpholineboron neutron capture therapyO-Carboraneheterocyclic system
ISSN
1420-3049
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/molecules23092194
Type
Article
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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