Preparation and in vitro release studies of ibuprofen loaded nanoparticles made from PHO and PEGMA-g-PHO

Abstract

Monoacrylate-poly(ethylene glycol) grafted poly(3-hydroxyoctanoate) (PEGMA-g-PHO) copolymer was obtained by UV irradiation and ibuprofen (IBU) loaded nanoparticles with PHO or PEGMA-g-PHO polymers were successfully prepared by a single emulsion process. Size of IBU-loaded nanoparticles was about 300 nm based on particle size measurement. Their shapes were spherical. To study drug release properties, IBU release from nanoparticles were performed with FBS buffer. Higher burst release of IBU was observed with the highest graft density of PEGMA groups and 100% drug release was found in 3, 6, and 12 days for PHO, PEGMA-g-PHO0.05, and PEGMA-g-PHO0.15, respectively. Our results suggest that hydrophobic PHO and more hydrophilic PEGMA-g-PHO could be regarded as good candidates of drug release carriers.