Nothofagin suppresses mast cell-mediated allergic inflammation = Nothofagin의 비만세포 연계 알러지염증 저해 효과

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dc.contributor.authorB C Kang-
dc.contributor.authorM J Kim-
dc.contributor.authorSoyoung Lee-
dc.contributor.authorY A Choi-
dc.contributor.authorP H Park-
dc.contributor.authorT Y Shin-
dc.contributor.authorT K Kwon-
dc.contributor.authorD Khang-
dc.contributor.authorS H Kim-
dc.date.accessioned2019-01-23T16:30:28Z-
dc.date.available2019-01-23T16:30:28Z-
dc.date.issued2019-
dc.identifier.issn0009-2797-
dc.identifier.uri10.1016/j.cbi.2018.10.025ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18163-
dc.description.abstractMast cells play a major role in immunoglobulin E-mediated allergic inflammation, which is involved in asthma, atopic dermatitis, and allergic rhinitis. Nothofagin has been shown to ameliorate various inflammatory responses such as the septic response and vascular inflammation. In this study, we assessed the inhibitory effect of nothofagin on allergic inflammation using cultured/isolated mast cells and an anaphylaxis mouse model. Nothofagin treatment prevented histamine and β-hexosaminidase release by reducing the influx of calcium into the cytosol in a concentration-dependent manner. Nothofagin also inhibited the gene expression and secretion of pro-inflammatory cytokines such as tumor necrosis factor-α and interleukin-4 by downregulating the phosphorylation of Lyn, Syk, Akt and nuclear translocation of nuclear factor-κB. To confirm these effects of nothofagin in vivo, we used a passive cutaneous anaphylaxis mouse model. Topical administration of nothofagin suppressed local pigmentation and ear thickness. Taken together, these results suggest nothofagin as a potential candidate for the treatment of mast cell-involved allergic inflammatory diseases.-
dc.publisherElsevier-
dc.titleNothofagin suppresses mast cell-mediated allergic inflammation = Nothofagin의 비만세포 연계 알러지염증 저해 효과-
dc.title.alternativeNothofagin suppresses mast cell-mediated allergic inflammation-
dc.typeArticle-
dc.citation.titleChemico-Biological Interactions-
dc.citation.number0-
dc.citation.endPage7-
dc.citation.startPage1-
dc.citation.volume298-
dc.contributor.affiliatedAuthorSoyoung Lee-
dc.contributor.alternativeName강병철-
dc.contributor.alternativeName김민종-
dc.contributor.alternativeName이소영-
dc.contributor.alternativeName최영애-
dc.contributor.alternativeName박필훈-
dc.contributor.alternativeName신태용-
dc.contributor.alternativeName권택규-
dc.contributor.alternativeName강동우-
dc.contributor.alternativeName김상현-
dc.identifier.bibliographicCitationChemico-Biological Interactions, vol. 298, pp. 1-7-
dc.identifier.doi10.1016/j.cbi.2018.10.025-
dc.subject.keywordAllergic inflammation-
dc.subject.keywordHistamine-
dc.subject.keywordMast cells-
dc.subject.keywordNothofagin-
dc.subject.localallergic inflammation-
dc.subject.localAllergic inflammation-
dc.subject.localHistamine-
dc.subject.localhistamine-
dc.subject.localMast cell-
dc.subject.localMast cells-
dc.subject.localmast cells-
dc.subject.localMast Cells-
dc.subject.localNothofagin-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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