Transient secondary structures as general target-binding motifs in intrinsically disordered proteins

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dc.contributor.authorDo-Hyoung Kim-
dc.contributor.authorKyou Hoon Han-
dc.date.accessioned2019-01-23T16:30:41Z-
dc.date.available2019-01-23T16:30:41Z-
dc.date.issued2018-
dc.identifier.issn1422-0067-
dc.identifier.uri10.3390/ijms19113614ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18197-
dc.description.abstractIntrinsically disordered proteins (IDPs) are unorthodox proteins that do not form three-dimensional structures under non-denaturing conditions, but perform important biological functions. In addition, IDPs are associated with many critical diseases including cancers, neurodegenerative diseases, and viral diseases. Due to the generic name of "unstructured" proteins used for IDPs in the early days, the notion that IDPs would be completely unstructured down to the level of secondary structures has prevailed for a long time. During the last two decades, ample evidence has been accumulated showing that IDPs in their target-free state are pre-populated with transient secondary structures critical for target binding. Nevertheless, such a message did not seem to have reached with sufficient clarity to the IDP or protein science community largely because similar but different expressions were used to denote the fundamentally same phenomenon of presence of such transient secondary structures, which is not surprising for a quickly evolving field. Here, we summarize the critical roles that these transient secondary structures play for diverse functions of IDPs by describing how various expressions referring to transient secondary structures have been used in different contexts.-
dc.publisherMDPI-
dc.titleTransient secondary structures as general target-binding motifs in intrinsically disordered proteins-
dc.title.alternativeTransient secondary structures as general target-binding motifs in intrinsically disordered proteins-
dc.typeArticle-
dc.citation.titleInternational Journal of Molecular Sciences-
dc.citation.number11-
dc.citation.endPage3614-
dc.citation.startPage3614-
dc.citation.volume19-
dc.contributor.affiliatedAuthorDo-Hyoung Kim-
dc.contributor.affiliatedAuthorKyou Hoon Han-
dc.contributor.alternativeName김도형-
dc.contributor.alternativeName한규훈-
dc.identifier.bibliographicCitationInternational Journal of Molecular Sciences, vol. 19, no. 11, pp. 3614-3614-
dc.identifier.doi10.3390/ijms19113614-
dc.subject.keywordintrinsically disordered protein (IDP)-
dc.subject.keywordpre-populated-
dc.subject.keywordpre-structured-
dc.subject.keywordtransient secondary structure-
dc.subject.localintrinsically disordered protein-
dc.subject.localIntrinsically disordered protein (IDP)-
dc.subject.localIntrinsically disordered protein-
dc.subject.localintrinsically disordered protein (IDP)-
dc.subject.localpre-populated-
dc.subject.localpre-structured-
dc.subject.localtransient secondary structure-
dc.description.journalClassY-
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Division of Bio Technology Innovation > Core Research Facility & Analysis Center > 1. Journal Articles
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