Lactic acid bacteria isolated from Kimchi to evaluate anti-obesity effect in high fat diet-induced obese mice

Abstract

Obesity is one of the major public concerns due to its various side-effects such as metabolic and chronic ailments. In this study, two lactic acid bacteria (LAB) strains, Leuconostoc mesenteroides and Lactobacillus sakei, isolated from Kimchi were investigated for their anti-obesity activity in obese mice model. To induce obesity in model mice (C57BL/6), high fat diet (HFD) with 60 kcal% fat was fed for 10 weeks. LAB supplementation reduced blood urea nitrogen, glucose, and triglyceride levels in serum from obesity induced mice. The study also observed significant decrease of fibro- sis, triglyceride, and total cholesterol level in fatty liver tissue by LAB supplementation. The results suggest that supplementation of L. mesenteroides and L. sakei could be used as alternative nutritional interventions to decrease symptoms caused by obesity with no safety or intolerance related problem.