DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dong Oh Kim | - |
dc.contributor.author | Jae-Eun Byun | - |
dc.contributor.author | H A Seong | - |
dc.contributor.author | Suk Ran Yoon | - |
dc.contributor.author | Inoyo Choi | - |
dc.contributor.author | Haiyoung Jung | - |
dc.date.accessioned | 2019-01-23T16:30:47Z | - |
dc.date.available | 2019-01-23T16:30:47Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | 10.1016/j.bbrc.2018.11.069 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/18213 | - |
dc.description.abstract | Inflammation comprises an innate immune response, and is mainly induced by macrophages to protect the host from pathogens and mechanical injuries. The p38 mitogen-activated protein kinase (MAPK) pathway is a key regulator of inflammatory responses in macrophages. Here, we investigated the anti-inflammatory effects of thioredoxin-interacting protein-derived peptide (TN13) in macrophages in vitro and in vivo. Human immunodeficiency virus (HIV) trans-activator protein (TAT)-conjugated TN13 (TAT-TN13) was found to penetrate RAW 264.7cells and decrease p38 MAPK activation in a dose-dependent manner. We also showed that TAT-TN13 could significantly inhibit lipopolysaccharide (LPS)-induced expression of macrophage activation-related receptors including CD80, CD86, and MHC II, as well as the transcriptional activation of nuclear factor-kappa B (NF-κB) and activator protein-1 (AP-1) in RAW 264.7cells and primary mouse splenic macrophages. Furthermore, TAT-TN13 decreased the LPS-induced production of proinflammatory cytokines and mediators such as tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), nitric oxide (NO), inducible NO synthase (iNOS), and cyclooxygenase 2 (COX-2) in RAW 264.7cells and mice. These results indicate that TAT-TN13 can inhibit macrophage-derived inflammation by inhibiting p38 MAPK activity and might represent a potential novel drug for the treatment of inflammation-related diseases. | - |
dc.publisher | Elsevier | - |
dc.title | Thioredoxin-interacting protein-derived peptide (TN13) inhibits LPS-induced inflammation by inhibiting p38 MAPK signaling | - |
dc.title.alternative | Thioredoxin-interacting protein-derived peptide (TN13) inhibits LPS-induced inflammation by inhibiting p38 MAPK signaling | - |
dc.type | Article | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 495 | - |
dc.citation.startPage | 489 | - |
dc.citation.volume | 507 | - |
dc.contributor.affiliatedAuthor | Dong Oh Kim | - |
dc.contributor.affiliatedAuthor | Jae-Eun Byun | - |
dc.contributor.affiliatedAuthor | Suk Ran Yoon | - |
dc.contributor.affiliatedAuthor | Inoyo Choi | - |
dc.contributor.affiliatedAuthor | Haiyoung Jung | - |
dc.contributor.alternativeName | 김동오 | - |
dc.contributor.alternativeName | 변재은 | - |
dc.contributor.alternativeName | 성현아 | - |
dc.contributor.alternativeName | 윤석란 | - |
dc.contributor.alternativeName | 최인표 | - |
dc.contributor.alternativeName | 정해용 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, vol. 507, no. 1, pp. 489-495 | - |
dc.identifier.doi | 10.1016/j.bbrc.2018.11.069 | - |
dc.subject.keyword | Inflammation | - |
dc.subject.keyword | LPS | - |
dc.subject.keyword | Macrophage | - |
dc.subject.keyword | TN13 | - |
dc.subject.keyword | TXNIP | - |
dc.subject.keyword | p38 MAPK | - |
dc.subject.local | Inflammation | - |
dc.subject.local | inflammation | - |
dc.subject.local | nflammation | - |
dc.subject.local | LPS | - |
dc.subject.local | macrophage | - |
dc.subject.local | macrophages | - |
dc.subject.local | Macrophage | - |
dc.subject.local | Macrophages | - |
dc.subject.local | TN13 | - |
dc.subject.local | TXNIP | - |
dc.subject.local | P38 MAPK | - |
dc.subject.local | p38 MAP kinase | - |
dc.subject.local | p38 MAPK | - |
dc.subject.local | p38 mitogen-activated protein kinase | - |
dc.subject.local | p38 mitogen-activated protein kinase (p38 MARK) | - |
dc.subject.local | p38MAPK | - |
dc.description.journalClass | Y | - |
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