Thioredoxin-interacting protein-derived peptide (TN13) inhibits LPS-induced inflammation by inhibiting p38 MAPK signaling

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dc.contributor.authorDong Oh Kim-
dc.contributor.authorJae-Eun Byun-
dc.contributor.authorH A Seong-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorInoyo Choi-
dc.contributor.authorHaiyoung Jung-
dc.date.accessioned2019-01-23T16:30:47Z-
dc.date.available2019-01-23T16:30:47Z-
dc.date.issued2018-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2018.11.069ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18213-
dc.description.abstractInflammation comprises an innate immune response, and is mainly induced by macrophages to protect the host from pathogens and mechanical injuries. The p38 mitogen-activated protein kinase (MAPK) pathway is a key regulator of inflammatory responses in macrophages. Here, we investigated the anti-inflammatory effects of thioredoxin-interacting protein-derived peptide (TN13) in macrophages in vitro and in vivo. Human immunodeficiency virus (HIV) trans-activator protein (TAT)-conjugated TN13 (TAT-TN13) was found to penetrate RAW 264.7cells and decrease p38 MAPK activation in a dose-dependent manner. We also showed that TAT-TN13 could significantly inhibit lipopolysaccharide (LPS)-induced expression of macrophage activation-related receptors including CD80, CD86, and MHC II, as well as the transcriptional activation of nuclear factor-kappa B (NF-κB) and activator protein-1 (AP-1) in RAW 264.7cells and primary mouse splenic macrophages. Furthermore, TAT-TN13 decreased the LPS-induced production of proinflammatory cytokines and mediators such as tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), nitric oxide (NO), inducible NO synthase (iNOS), and cyclooxygenase 2 (COX-2) in RAW 264.7cells and mice. These results indicate that TAT-TN13 can inhibit macrophage-derived inflammation by inhibiting p38 MAPK activity and might represent a potential novel drug for the treatment of inflammation-related diseases.-
dc.publisherElsevier-
dc.titleThioredoxin-interacting protein-derived peptide (TN13) inhibits LPS-induced inflammation by inhibiting p38 MAPK signaling-
dc.title.alternativeThioredoxin-interacting protein-derived peptide (TN13) inhibits LPS-induced inflammation by inhibiting p38 MAPK signaling-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number1-
dc.citation.endPage495-
dc.citation.startPage489-
dc.citation.volume507-
dc.contributor.affiliatedAuthorDong Oh Kim-
dc.contributor.affiliatedAuthorJae-Eun Byun-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorInoyo Choi-
dc.contributor.affiliatedAuthorHaiyoung Jung-
dc.contributor.alternativeName김동오-
dc.contributor.alternativeName변재은-
dc.contributor.alternativeName성현아-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName최인표-
dc.contributor.alternativeName정해용-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 507, no. 1, pp. 489-495-
dc.identifier.doi10.1016/j.bbrc.2018.11.069-
dc.subject.keywordInflammation-
dc.subject.keywordLPS-
dc.subject.keywordMacrophage-
dc.subject.keywordTN13-
dc.subject.keywordTXNIP-
dc.subject.keywordp38 MAPK-
dc.subject.localInflammation-
dc.subject.localinflammation-
dc.subject.localnflammation-
dc.subject.localLPS-
dc.subject.localmacrophage-
dc.subject.localmacrophages-
dc.subject.localMacrophage-
dc.subject.localMacrophages-
dc.subject.localTN13-
dc.subject.localTXNIP-
dc.subject.localP38 MAPK-
dc.subject.localp38 MAP kinase-
dc.subject.localp38 MAPK-
dc.subject.localp38 mitogen-activated protein kinase-
dc.subject.localp38 mitogen-activated protein kinase (p38 MARK)-
dc.subject.localp38MAPK-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
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