Bcl-2-dependent synthetic lethal interaction of the IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer = 대장암에서의 Bcl-2-의존적인 IDF-11774와 ATP6V0C 합성치사

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dc.contributor.authorBo Kyung Kim-
dc.contributor.authorS W Nam-
dc.contributor.authorB S Min-
dc.contributor.authorHyun Seung Ban-
dc.contributor.authorS Paik-
dc.contributor.authorK Lee-
dc.contributor.authorJoo-Young Im-
dc.contributor.authorYoungjoo Lee-
dc.contributor.authorJ T Park-
dc.contributor.authorSeon-Young Kim-
dc.contributor.authorMirang Kim-
dc.contributor.authorH Lee-
dc.contributor.authorMi Sun Won-
dc.date.accessioned2019-01-23T16:30:54Z-
dc.date.available2019-01-23T16:30:54Z-
dc.date.issued2018-
dc.identifier.issn0007-0920-
dc.identifier.uri10.1038/s41416-018-0289-1ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18236-
dc.description.abstractBACKGROUND: The IDF-11774, a novel clinical candidate for cancer therapy, targets HSP70 and inhibits mitochondrial respiration, resulting in the activation of AMPK and reduction in HIF-1α accumulation. METHODS: To identify genes that have synthetic lethality to IDF-11774, RNA interference screening was conducted, using pooled lentiviruses expressing a short hairpin RNA library. RESULTS: We identified ATP6V0C, encoding the V0 subunit C of lysosomal V-ATPase, knockdown of which induced a synergistic growth-inhibitory effect in HCT116 cells in the presence of IDF-11774. The synthetic lethality of IDF-11774 with ATP6V0C possibly correlates with IDF-11774-mediated autolysosome formation. Notably, the synergistic effect of IDF-11774 and the ATP6V0C inhibitor, bafilomycin A1, depended on the PIK3CA genetic status and Bcl-2 expression, which regulates autolysosome formation and apoptosis. Similarly, in an experiment using conditionally reprogramed cells derived from colorectal cancer patients, synergistic growth inhibition was observed in cells with low Bcl-2 expression. CONCLUSIONS: Bcl-2 is a biomarker for the synthetic lethal interaction of IDF-11774 with ATP6V0C, which is clinically applicable for the treatment of cancer patients with IDF-11774 or autophagy-inducing anti-cancer drugs.-
dc.publisherSpringer-Nature Pub Group-
dc.titleBcl-2-dependent synthetic lethal interaction of the IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer = 대장암에서의 Bcl-2-의존적인 IDF-11774와 ATP6V0C 합성치사-
dc.title.alternativeBcl-2-dependent synthetic lethal interaction of the IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer-
dc.typeArticle-
dc.citation.titleBritish Journal of Cancer-
dc.citation.number11-
dc.citation.endPage1357-
dc.citation.startPage1347-
dc.citation.volume119-
dc.contributor.affiliatedAuthorBo Kyung Kim-
dc.contributor.affiliatedAuthorHyun Seung Ban-
dc.contributor.affiliatedAuthorJoo-Young Im-
dc.contributor.affiliatedAuthorSeon-Young Kim-
dc.contributor.affiliatedAuthorMirang Kim-
dc.contributor.affiliatedAuthorMi Sun Won-
dc.contributor.alternativeName김보경-
dc.contributor.alternativeName남순우-
dc.contributor.alternativeName민병소-
dc.contributor.alternativeName반현승-
dc.contributor.alternativeName백순명-
dc.contributor.alternativeName이경-
dc.contributor.alternativeName임주영-
dc.contributor.alternativeName이영주-
dc.contributor.alternativeName박준태-
dc.contributor.alternativeName김선영-
dc.contributor.alternativeName김미랑-
dc.contributor.alternativeName이홍섭-
dc.contributor.alternativeName원미선-
dc.identifier.bibliographicCitationBritish Journal of Cancer, vol. 119, no. 11, pp. 1347-1357-
dc.identifier.doi10.1038/s41416-018-0289-1-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
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