DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bo Kyung Kim | - |
dc.contributor.author | S W Nam | - |
dc.contributor.author | B S Min | - |
dc.contributor.author | Hyun Seung Ban | - |
dc.contributor.author | S Paik | - |
dc.contributor.author | K Lee | - |
dc.contributor.author | Joo-Young Im | - |
dc.contributor.author | Youngjoo Lee | - |
dc.contributor.author | J T Park | - |
dc.contributor.author | Seon-Young Kim | - |
dc.contributor.author | Mirang Kim | - |
dc.contributor.author | H Lee | - |
dc.contributor.author | Mi Sun Won | - |
dc.date.accessioned | 2019-01-23T16:30:54Z | - |
dc.date.available | 2019-01-23T16:30:54Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0007-0920 | - |
dc.identifier.uri | 10.1038/s41416-018-0289-1 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/18236 | - |
dc.description.abstract | BACKGROUND: The IDF-11774, a novel clinical candidate for cancer therapy, targets HSP70 and inhibits mitochondrial respiration, resulting in the activation of AMPK and reduction in HIF-1α accumulation. METHODS: To identify genes that have synthetic lethality to IDF-11774, RNA interference screening was conducted, using pooled lentiviruses expressing a short hairpin RNA library. RESULTS: We identified ATP6V0C, encoding the V0 subunit C of lysosomal V-ATPase, knockdown of which induced a synergistic growth-inhibitory effect in HCT116 cells in the presence of IDF-11774. The synthetic lethality of IDF-11774 with ATP6V0C possibly correlates with IDF-11774-mediated autolysosome formation. Notably, the synergistic effect of IDF-11774 and the ATP6V0C inhibitor, bafilomycin A1, depended on the PIK3CA genetic status and Bcl-2 expression, which regulates autolysosome formation and apoptosis. Similarly, in an experiment using conditionally reprogramed cells derived from colorectal cancer patients, synergistic growth inhibition was observed in cells with low Bcl-2 expression. CONCLUSIONS: Bcl-2 is a biomarker for the synthetic lethal interaction of IDF-11774 with ATP6V0C, which is clinically applicable for the treatment of cancer patients with IDF-11774 or autophagy-inducing anti-cancer drugs. | - |
dc.publisher | Springer-Nature Pub Group | - |
dc.title | Bcl-2-dependent synthetic lethal interaction of the IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer = 대장암에서의 Bcl-2-의존적인 IDF-11774와 ATP6V0C 합성치사 | - |
dc.title.alternative | Bcl-2-dependent synthetic lethal interaction of the IDF-11774 with the V0 subunit C of vacuolar ATPase (ATP6V0C) in colorectal cancer | - |
dc.type | Article | - |
dc.citation.title | British Journal of Cancer | - |
dc.citation.number | 11 | - |
dc.citation.endPage | 1357 | - |
dc.citation.startPage | 1347 | - |
dc.citation.volume | 119 | - |
dc.contributor.affiliatedAuthor | Bo Kyung Kim | - |
dc.contributor.affiliatedAuthor | Hyun Seung Ban | - |
dc.contributor.affiliatedAuthor | Joo-Young Im | - |
dc.contributor.affiliatedAuthor | Seon-Young Kim | - |
dc.contributor.affiliatedAuthor | Mirang Kim | - |
dc.contributor.affiliatedAuthor | Mi Sun Won | - |
dc.contributor.alternativeName | 김보경 | - |
dc.contributor.alternativeName | 남순우 | - |
dc.contributor.alternativeName | 민병소 | - |
dc.contributor.alternativeName | 반현승 | - |
dc.contributor.alternativeName | 백순명 | - |
dc.contributor.alternativeName | 이경 | - |
dc.contributor.alternativeName | 임주영 | - |
dc.contributor.alternativeName | 이영주 | - |
dc.contributor.alternativeName | 박준태 | - |
dc.contributor.alternativeName | 김선영 | - |
dc.contributor.alternativeName | 김미랑 | - |
dc.contributor.alternativeName | 이홍섭 | - |
dc.contributor.alternativeName | 원미선 | - |
dc.identifier.bibliographicCitation | British Journal of Cancer, vol. 119, no. 11, pp. 1347-1357 | - |
dc.identifier.doi | 10.1038/s41416-018-0289-1 | - |
dc.description.journalClass | Y | - |
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