Vaccine synergy with virus-like particle and immune complex platforms for delivery of human papillomavirus L2 antigen = HPV L2 항원 전달을 위한 VLP와 ICP의 백신 시너지

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Title
Vaccine synergy with virus-like particle and immune complex platforms for delivery of human papillomavirus L2 antigen = HPV L2 항원 전달을 위한 VLP와 ICP의 백신 시너지
Author(s)
A G Diamos; D Larios; L Brown; J Kilbourne; Hyun Soon Kim; D Saxena; K E Palmer; H S Mason
Bibliographic Citation
Vaccine, vol. 37, no. 1, pp. 137-144
Publication Year
2019
Abstract
Diverse HPV subtypes are responsible for considerable disease burden worldwide, necessitating safe, cheap, and effective vaccines. The HPV minor capsid protein L2 is a promising candidate to create broadly protective HPV vaccines, though it is poorly immunogenic by itself. To create highly immunogenic and safe vaccine candidates targeting L2, we employed a plant-based recombinant protein expression system to produce two different vaccine candidates: L2 displayed on the surface of hepatitis B core (HBc) virus-like particles (VLPs) or L2 genetically fused to an immunoglobulin capable of forming recombinant immune complexes (RIC). Both vaccine candidates were potently immunogenic in mice, but were especially so when delivered together, generating very consistent and high antibody titers directed against HPV L2 (>1,000,000) that correlated with virus neutralization. These data indicate a novel immune response synergy upon co-delivery of VLP and RIC platforms, a strategy that can be adapted generally for many different antigens.
Keyword
Human papillomavirusMinor capsid proteinRecombinant immune complexVaccineVirus-like particle
ISSN
0264-410X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.vaccine.2018.11.021
Type
Article
Appears in Collections:
Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
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