DC Field | Value | Language |
---|---|---|
dc.contributor.author | Young Lai Cho | - |
dc.contributor.author | Jong Gil Park | - |
dc.contributor.author | H J Kang | - |
dc.contributor.author | Wooil Kim | - |
dc.contributor.author | Min Ji Cho | - |
dc.contributor.author | Ju Hong Jang | - |
dc.contributor.author | Min-Gi Kwon | - |
dc.contributor.author | Sungsik Kim | - |
dc.contributor.author | Sang Hyun Lee | - |
dc.contributor.author | Jangwook Lee | - |
dc.contributor.author | Yeon-Gu Kim | - |
dc.contributor.author | Young-Jun Park | - |
dc.contributor.author | Won Kon Kim | - |
dc.contributor.author | Kwang-Hee Bae | - |
dc.contributor.author | Byoung-Mog Kwon | - |
dc.contributor.author | S J Chung | - |
dc.contributor.author | Jeong Ki Min | - |
dc.date.accessioned | 2019-01-23T16:31:04Z | - |
dc.date.available | 2019-01-23T16:31:04Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1043-6618 | - |
dc.identifier.uri | 10.1016/j.phrs.2018.11.027 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/18268 | - |
dc.description.abstract | Adipogenesis involved in hypertrophy and hyperplasia of adipocytes is responsible for expanding the mass of adipose tissues in obese individuals. Peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα) are two principal transcription factors induced by delicate signaling pathways, including signal transducer and activator of transcription 5 (STAT5), in adipogenesis. Here, we demonstrated a novel role of ginkgetin, a biflavone from Ginkgo biloba leaves, as a STAT5 inhibitor that blocks the differentiation of preadipocytes into adipocytes. During the differentiation of 3T3-L1 cells, ginkgetin treatment during the first 2 days markedly inhibited the formation of lipid-bearing adipocytes. PPARγ and C/EBPα expression was decreased in 3T3-L1 cells during adipogenesis following ginkgetin treatment, whereas no change was observed in C/EBPβ or C/EBPδ expression. Inhibition of PPARγ and C/EBPα expression by ginkgetin occurred through the prevention of STAT5 activation during the initiation phase of adipogenesis. In addition, ginkgetin-mediated the inhibition of adipogenesis was recapitulated in the differentiation of primary preadipocytes. Lastly, we confirmed the inhibitory effects of ginkgetin on the hypertrophy of white adipose tissues from high-fat diet-fed mice. These results indicate that ginkgetin is a potential anti-adipogenesis and anti-obesity drug. | - |
dc.publisher | Elsevier | - |
dc.title | Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation | - |
dc.title.alternative | Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation | - |
dc.type | Article | - |
dc.citation.title | Pharmacological Research | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 336 | - |
dc.citation.startPage | 325 | - |
dc.citation.volume | 139 | - |
dc.contributor.affiliatedAuthor | Young Lai Cho | - |
dc.contributor.affiliatedAuthor | Jong Gil Park | - |
dc.contributor.affiliatedAuthor | Wooil Kim | - |
dc.contributor.affiliatedAuthor | Min Ji Cho | - |
dc.contributor.affiliatedAuthor | Ju Hong Jang | - |
dc.contributor.affiliatedAuthor | Min-Gi Kwon | - |
dc.contributor.affiliatedAuthor | Sungsik Kim | - |
dc.contributor.affiliatedAuthor | Sang Hyun Lee | - |
dc.contributor.affiliatedAuthor | Jangwook Lee | - |
dc.contributor.affiliatedAuthor | Yeon-Gu Kim | - |
dc.contributor.affiliatedAuthor | Young-Jun Park | - |
dc.contributor.affiliatedAuthor | Won Kon Kim | - |
dc.contributor.affiliatedAuthor | Kwang-Hee Bae | - |
dc.contributor.affiliatedAuthor | Byoung-Mog Kwon | - |
dc.contributor.affiliatedAuthor | Jeong Ki Min | - |
dc.contributor.alternativeName | 조영래 | - |
dc.contributor.alternativeName | 박종길 | - |
dc.contributor.alternativeName | 강효진 | - |
dc.contributor.alternativeName | 김우일 | - |
dc.contributor.alternativeName | 조민지 | - |
dc.contributor.alternativeName | 장주홍 | - |
dc.contributor.alternativeName | 권민기 | - |
dc.contributor.alternativeName | 김성식 | - |
dc.contributor.alternativeName | 이상현 | - |
dc.contributor.alternativeName | 이장욱 | - |
dc.contributor.alternativeName | 김연구 | - |
dc.contributor.alternativeName | 박영준 | - |
dc.contributor.alternativeName | 김원곤 | - |
dc.contributor.alternativeName | 배광희 | - |
dc.contributor.alternativeName | 권병목 | - |
dc.contributor.alternativeName | 정상전 | - |
dc.contributor.alternativeName | 민정기 | - |
dc.identifier.bibliographicCitation | Pharmacological Research, vol. 139, pp. 325-336 | - |
dc.identifier.doi | 10.1016/j.phrs.2018.11.027 | - |
dc.subject.keyword | Adipogenesis | - |
dc.subject.keyword | CCAAT/enhancer-binding protein α (C/EBPα) | - |
dc.subject.keyword | Ginkgetin | - |
dc.subject.keyword | Obesity | - |
dc.subject.keyword | Peroxisome proliferator-activated receptor γ(PPARγ) | - |
dc.subject.keyword | Signal transducer and activator of transcription 5 (STAT5) | - |
dc.subject.local | ADIPOGENESIS | - |
dc.subject.local | Adipogenesis | - |
dc.subject.local | adipogenesis | - |
dc.subject.local | CCAAT/enhancer binding protein-α | - |
dc.subject.local | CCAAT/enhancer-binding protein α (C/EBPα) | - |
dc.subject.local | Ginkgetin | - |
dc.subject.local | Obesity | - |
dc.subject.local | obesity | - |
dc.subject.local | Peroxisome proliferator-activated receptor γ(PPARγ) | - |
dc.subject.local | STAT5 | - |
dc.subject.local | Signal transducer and activator of transcription 5 (STAT5) | - |
dc.description.journalClass | Y | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.