Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation

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dc.contributor.authorYoung Lai Cho-
dc.contributor.authorJong Gil Park-
dc.contributor.authorH J Kang-
dc.contributor.authorWooil Kim-
dc.contributor.authorMin Ji Jo-
dc.contributor.authorJu Hong Jang-
dc.contributor.authorMin-Gi Kwon-
dc.contributor.authorSungsik Kim-
dc.contributor.authorSang Hyun Lee-
dc.contributor.authorJangwook Lee-
dc.contributor.authorYeon-Gu Kim-
dc.contributor.authorYoung-Jun Park-
dc.contributor.authorWon Kon Kim-
dc.contributor.authorKwang-Hee Bae-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorS J Chung-
dc.contributor.authorJeong Ki Min-
dc.date.accessioned2019-01-23T16:31:04Z-
dc.date.available2019-01-23T16:31:04Z-
dc.date.issued2019-
dc.identifier.issn1043-6618-
dc.identifier.uri10.1016/j.phrs.2018.11.027ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18268-
dc.description.abstractAdipogenesis involved in hypertrophy and hyperplasia of adipocytes is responsible for expanding the mass of adipose tissues in obese individuals. Peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα) are two principal transcription factors induced by delicate signaling pathways, including signal transducer and activator of transcription 5 (STAT5), in adipogenesis. Here, we demonstrated a novel role of ginkgetin, a biflavone from Ginkgo biloba leaves, as a STAT5 inhibitor that blocks the differentiation of preadipocytes into adipocytes. During the differentiation of 3T3-L1 cells, ginkgetin treatment during the first 2 days markedly inhibited the formation of lipid-bearing adipocytes. PPARγ and C/EBPα expression was decreased in 3T3-L1 cells during adipogenesis following ginkgetin treatment, whereas no change was observed in C/EBPβ or C/EBPδ expression. Inhibition of PPARγ and C/EBPα expression by ginkgetin occurred through the prevention of STAT5 activation during the initiation phase of adipogenesis. In addition, ginkgetin-mediated the inhibition of adipogenesis was recapitulated in the differentiation of primary preadipocytes. Lastly, we confirmed the inhibitory effects of ginkgetin on the hypertrophy of white adipose tissues from high-fat diet-fed mice. These results indicate that ginkgetin is a potential anti-adipogenesis and anti-obesity drug.-
dc.publisherElsevier-
dc.titleGinkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation-
dc.title.alternativeGinkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation-
dc.typeArticle-
dc.citation.titlePharmacological Research-
dc.citation.number0-
dc.citation.endPage336-
dc.citation.startPage325-
dc.citation.volume139-
dc.contributor.affiliatedAuthorYoung Lai Cho-
dc.contributor.affiliatedAuthorJong Gil Park-
dc.contributor.affiliatedAuthorWooil Kim-
dc.contributor.affiliatedAuthorMin Ji Jo-
dc.contributor.affiliatedAuthorJu Hong Jang-
dc.contributor.affiliatedAuthorMin-Gi Kwon-
dc.contributor.affiliatedAuthorSungsik Kim-
dc.contributor.affiliatedAuthorSang Hyun Lee-
dc.contributor.affiliatedAuthorJangwook Lee-
dc.contributor.affiliatedAuthorYeon-Gu Kim-
dc.contributor.affiliatedAuthorYoung-Jun Park-
dc.contributor.affiliatedAuthorWon Kon Kim-
dc.contributor.affiliatedAuthorKwang-Hee Bae-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.affiliatedAuthorJeong Ki Min-
dc.contributor.alternativeName조영래-
dc.contributor.alternativeName박종길-
dc.contributor.alternativeName강효진-
dc.contributor.alternativeName김우일-
dc.contributor.alternativeName조민지-
dc.contributor.alternativeName장주홍-
dc.contributor.alternativeName권민기-
dc.contributor.alternativeName김성식-
dc.contributor.alternativeName이상현-
dc.contributor.alternativeName이장욱-
dc.contributor.alternativeName김연구-
dc.contributor.alternativeName박영준-
dc.contributor.alternativeName김원곤-
dc.contributor.alternativeName배광희-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName정상전-
dc.contributor.alternativeName민정기-
dc.identifier.bibliographicCitationPharmacological Research, vol. 139, pp. 325-336-
dc.identifier.doi10.1016/j.phrs.2018.11.027-
dc.subject.keywordAdipogenesis-
dc.subject.keywordCCAAT/enhancer-binding protein α (C/EBPα)-
dc.subject.keywordGinkgetin-
dc.subject.keywordObesity-
dc.subject.keywordPeroxisome proliferator-activated receptor γ(PPARγ)-
dc.subject.keywordSignal transducer and activator of transcription 5 (STAT5)-
dc.subject.localadipogenesis-
dc.subject.localADIPOGENESIS-
dc.subject.localAdipogenesis-
dc.subject.localCCAAT/enhancer binding protein-α-
dc.subject.localCCAAT/enhancer-binding protein α (C/EBPα)-
dc.subject.localGinkgetin-
dc.subject.localObesity-
dc.subject.localobesity-
dc.subject.localPeroxisome proliferator-activated receptor γ(PPARγ)-
dc.subject.localSignal transducer and activator of transcription 5 (STAT5)-
dc.subject.localSTAT5-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
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