Effect of Veratrum maackii on testosterone propionate-induced benign prostatic hyperplasia in rats

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dc.contributor.authorH S Park-
dc.contributor.authorC S Seo-
dc.contributor.authorC U B Wijerathne-
dc.contributor.authorH Y Jeong-
dc.contributor.authorOg Sung Moon-
dc.contributor.authorYoung Won Seo-
dc.contributor.authorYoung Suk Won-
dc.contributor.authorH Y Son-
dc.contributor.authorJ H Lim-
dc.contributor.authorH J Kwun-
dc.date.accessioned2019-01-23T16:31:13Z-
dc.date.available2019-01-23T16:31:13Z-
dc.date.issued2019-
dc.identifier.issn0918-6158-
dc.identifier.uri10.1248/bpb.b18-00313ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/18298-
dc.description.abstractVeratrum maackii (VM), a perennial plant in the Melanthiaceae family, has anti-hypertensive, anti-cholinergic, anti-asthmatic, anti-tussive, anti-fungal, anti-melanogenesis, and anti-tumor activities. Here, we investigated the therapeutic effect of VM on benign prostatic hyperplasia (BPH) in human normal prostate cell line (WPMY-1) and a testosterone propionate-induced BPH animal model. WPMY-1 cells were treated with VM (1-10 μg/mL) and testosterone propionate (100nM). BPH in rats was generated via daily subcutaneous injections of testosterone propionate (3mg/kg) dissolved in corn oil, for 4 weeks. VM (150mg/kg) was administered daily for 4 weeks by oral gavage concurrently with the testosterone propionate. All rats were sacrificed and the prostates were dissected, weighed, and subjected to histological, immunohistochemical, and biochemical examinations. Immunoblotting experiments indicated that WPMY-1 cells treated testosterone propionate had increased expression of prostate specific antigen (PSA) and androgen receptor (AR), and treatment with VM or finasteride blocked this effect. In rat model, VM significantly reduced prostate weight, prostatic hyperplasia, prostatic levels of dihydrotestosterone (DHT), and expression of proliferation markers such as proliferating cell nuclear antigen (PCNA) and cyclin D1, but increased the expression of pro-apoptotic Bcl-2-associated X protein (Bax) and the cleavage of caspase-3. VM administration also suppressed the testosterone propionate-induced activation of nuclear factor-kappaB (NF-κB). Our results indicate that VM effectively represses the development of testosterone propionate-induced BPH, suggesting it may be a useful treatment agent for BPH.-
dc.publisherPharmaceutical Soc Japan-
dc.titleEffect of Veratrum maackii on testosterone propionate-induced benign prostatic hyperplasia in rats-
dc.title.alternativeEffect of Veratrum maackii on testosterone propionate-induced benign prostatic hyperplasia in rats-
dc.typeArticle-
dc.citation.titleBiological & Pharmaceutical Bulletin-
dc.citation.number1-
dc.citation.endPage9-
dc.citation.startPage1-
dc.citation.volume42-
dc.contributor.affiliatedAuthorOg Sung Moon-
dc.contributor.affiliatedAuthorYoung Won Seo-
dc.contributor.affiliatedAuthorYoung Suk Won-
dc.contributor.alternativeName박희선-
dc.contributor.alternativeName서창섭-
dc.contributor.alternativeNameWijerathne-
dc.contributor.alternativeName정혜윤-
dc.contributor.alternativeName문옥성-
dc.contributor.alternativeName서영원-
dc.contributor.alternativeName원영석-
dc.contributor.alternativeName손화영-
dc.contributor.alternativeName임종환-
dc.contributor.alternativeName권효정-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, vol. 42, no. 1, pp. 1-9-
dc.identifier.doi10.1248/bpb.b18-00313-
dc.subject.keywordVeratrum maackii-
dc.subject.keywordbenign prostatic hyperplasia-
dc.subject.keywordnuclear factor-kappaB (NF-κB)-
dc.subject.keywordtestosterone propionate-
dc.subject.localVeratrum maackii-
dc.subject.localBenign prostatic hyperplasia-
dc.subject.localbenign prostatic hyperplasia-
dc.subject.localNuclear factor-kappa B-
dc.subject.localnuclear factor κB-
dc.subject.localNf-κb-
dc.subject.localNF-kB-
dc.subject.localnuclear factor kappa B-
dc.subject.localNF-κB (nuclear factor kappa-B)-
dc.subject.localNF-kappaB-
dc.subject.localNuclear factor-κb-
dc.subject.localNF-κ B-
dc.subject.localNF-κB-
dc.subject.localNF-kappa B-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localNuclear factor κB-
dc.subject.localNFκB-
dc.subject.localNf-κB-
dc.subject.localNuclear factor-κB-
dc.subject.localnuclear factorκB-
dc.subject.localNuclear factor (NF)-κB-
dc.subject.localNuclear factor kappa B-
dc.subject.localnuclear factor-κB-
dc.subject.localNF-ΚB-
dc.subject.localNuclear factor-kappa B (NF-κB)-
dc.subject.localNuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB (NF-κB)-
dc.subject.localNFkappaB-
dc.subject.localNuclear factor kappaB-
dc.subject.localtestosterone propionate-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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